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Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies

BACKGROUND: The association between gonorrhea and prostate cancer risk has been investigated widely, but the results remain inconsistent and contradictory. We conducted an updated meta-analysis to obtain a more precise estimate of this association. MATERIAL/METHODS: PubMed, EMBASE, and the Cochrane...

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Autores principales: Lian, Wen-Qing, Luo, Fei, Song, Xian-Lu, Lu, Yong-Jie, Zhao, Shan-Chao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502545/
https://www.ncbi.nlm.nih.gov/pubmed/26126881
http://dx.doi.org/10.12659/MSM.893579
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author Lian, Wen-Qing
Luo, Fei
Song, Xian-Lu
Lu, Yong-Jie
Zhao, Shan-Chao
author_facet Lian, Wen-Qing
Luo, Fei
Song, Xian-Lu
Lu, Yong-Jie
Zhao, Shan-Chao
author_sort Lian, Wen-Qing
collection PubMed
description BACKGROUND: The association between gonorrhea and prostate cancer risk has been investigated widely, but the results remain inconsistent and contradictory. We conducted an updated meta-analysis to obtain a more precise estimate of this association. MATERIAL/METHODS: PubMed, EMBASE, and the Cochrane Library were searched for papers up to June 2014 to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the influence of gonorrhea on prostate cancer risk. RESULTS: Twenty-one observational studies (19 case-control and 2 cohort) were eligible, comprising 9965 prostate cancer patients and 118 765 participants. Pooled results indicated that gonorrhea was significantly associated with increased incidence of prostate cancer (OR 1.31, 95% CI 1.14–1.52). The association between gonorrhea and prostate cancer was stronger in African American males (OR 1.32, 95% CI 1.06–1.65) than in Whites (OR 1.05, 95% CI 0.90–1.21). CONCLUSIONS: Our findings suggest that gonorrhea is associated with an increased risk of prostate cancer, especially among African American males. These results warrant further well-designed, large-scale cohort studies to draw definitive conclusions.
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spelling pubmed-45025452015-07-17 Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies Lian, Wen-Qing Luo, Fei Song, Xian-Lu Lu, Yong-Jie Zhao, Shan-Chao Med Sci Monit Meta-Analysis BACKGROUND: The association between gonorrhea and prostate cancer risk has been investigated widely, but the results remain inconsistent and contradictory. We conducted an updated meta-analysis to obtain a more precise estimate of this association. MATERIAL/METHODS: PubMed, EMBASE, and the Cochrane Library were searched for papers up to June 2014 to identify eligible studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the influence of gonorrhea on prostate cancer risk. RESULTS: Twenty-one observational studies (19 case-control and 2 cohort) were eligible, comprising 9965 prostate cancer patients and 118 765 participants. Pooled results indicated that gonorrhea was significantly associated with increased incidence of prostate cancer (OR 1.31, 95% CI 1.14–1.52). The association between gonorrhea and prostate cancer was stronger in African American males (OR 1.32, 95% CI 1.06–1.65) than in Whites (OR 1.05, 95% CI 0.90–1.21). CONCLUSIONS: Our findings suggest that gonorrhea is associated with an increased risk of prostate cancer, especially among African American males. These results warrant further well-designed, large-scale cohort studies to draw definitive conclusions. International Scientific Literature, Inc. 2015-07-01 /pmc/articles/PMC4502545/ /pubmed/26126881 http://dx.doi.org/10.12659/MSM.893579 Text en © Med Sci Monit, 2015 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Meta-Analysis
Lian, Wen-Qing
Luo, Fei
Song, Xian-Lu
Lu, Yong-Jie
Zhao, Shan-Chao
Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title_full Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title_fullStr Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title_full_unstemmed Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title_short Gonorrhea and Prostate Cancer Incidence: An Updated Meta-Analysis of 21 Epidemiologic Studies
title_sort gonorrhea and prostate cancer incidence: an updated meta-analysis of 21 epidemiologic studies
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502545/
https://www.ncbi.nlm.nih.gov/pubmed/26126881
http://dx.doi.org/10.12659/MSM.893579
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