Palmitate induces cisternal ER expansion via the activation of XBP-1/CCTα-mediated phospholipid accumulation in RAW 264.7 cells

BACKGROUND: Endoplasmic reticulum (ER) stress induces ER expansion. The expansion of the intracisternal space of the ER was found in macrophages associated with human atherosclerotic lesions. We also previously reported that palmitate induces cisternal ER expansion and necrosis in RAW 264.7 cells. I...

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Detalles Bibliográficos
Autores principales: Kim, Seong Keun, Oh, Eunhye, Yun, Mihee, Lee, Seong-Beom, Chae, Gue Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502558/
https://www.ncbi.nlm.nih.gov/pubmed/26174230
http://dx.doi.org/10.1186/s12944-015-0077-3

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