Cargando…

Role of Raf-kinase inhibitor protein in colorectal cancer and its regulation by hydroxycamptothecine

BACKGROUND: Recently accumulated evidence suggests that Raf kinase inhibitor protein (RKIP) participates in regulation of many signaling pathways and plays an important role in tumorigenesis and tumor metastasis. However, studies investigating the role of RKIP in colorectal cancer have not been repo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nie, Fang, Cao, Jianguo, Tong, Jinlu, Zhu, Mingming, Gao, Yuan, Ran, Zhihua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502602/ https://www.ncbi.nlm.nih.gov/pubmed/26177829 http://dx.doi.org/10.1186/s12929-015-0162-y

Ejemplares similares

Effect of verapamil on the pharmacokinetics of hydroxycamptothecin and its potential mechanism
por: Xing, Hua, et al.
Publicado: (2020)

RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis
por: Zebisch, Armin, et al.
Publicado: (2019)

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors
por: Marusiak, Anna A., et al.
Publicado: (2014)

Synthetic high-density lipoproteins for delivery of 10-hydroxycamptothecin
por: Yuan, Yue, et al.
Publicado: (2016)

Neddylation inhibitor MLN4924 sensitizes head and neck squamous carcinoma cells to (S)-10-hydroxycamptothecin
por: Gu, Shanshan, et al.
Publicado: (2023)

Structure and RAF family kinase isoform selectivity of type II RAF inhibitors tovorafenib and naporafenib
por: Tkacik, Emre, et al.
Publicado: (2023)

Antitumor Mechanism of Hydroxycamptothecin via the Metabolic Perturbation of Ribonucleotide and Deoxyribonucleotide in Human Colorectal Carcinoma Cells
por: Li, Yan, et al.
Publicado: (2021)

Targeting the Raf kinases in human cancer: the Raf dimer dilemma
por: Durrant, David E, et al.
Publicado: (2018)

Mechanism and consequences of RAF kinase activation by small-molecule inhibitors
por: Holderfield, M, et al.
Publicado: (2014)

The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion
por: Liang, Yuan, et al.
Publicado: (2014)

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition
por: Jin, Ting, et al.
Publicado: (2017)

Menthol-modified casein nanoparticles loading 10-hydroxycamptothecin for glioma targeting therapy
por: Gao, Caifang, et al.
Publicado: (2019)

Arabidopsis Raf-Like Kinase Raf10 Is a Regulatory Component of Core ABA Signaling
por: Nguyen, Quy Thi Cam, et al.
Publicado: (2019)

An Investigation of Molecular Docking and Molecular Dynamic Simulation on Imidazopyridines as B-Raf Kinase Inhibitors
por: Xie, Huiding, et al.
Publicado: (2015)

Optogenetically controlled RAF to characterize BRAF and CRAF protein kinase inhibitors
por: Chatelle, Claire V., et al.
Publicado: (2016)

The effect of hydroxycamptothecin and pingyangmycin on human squamous cell carcinoma of the tongue
por: CHEN, PENG, et al.
Publicado: (2013)

The Role of Glucuronidation in 7‐Ethyl‐10‐hydroxycamptothecin Resistance in vitro
por: Takahashi, Toshiaki, et al.
Publicado: (1997)

Advances in Antitumor Nano-Drug Delivery Systems of 10-Hydroxycamptothecin
por: Chen, Yukun, et al.
Publicado: (2022)

Liraglutide inhibits the progression of prediabetes in rats by reducing Raf-1 kinase inhibitor protein
por: Gao, Fei, et al.
Publicado: (2021)

Increased chemoresistance via Snail–Raf kinase inhibitor protein signaling in colorectal cancer in response to a nicotine derivative
por: Lee, Tsai-Yu, et al.
Publicado: (2016)

Hydroxycamptothecin mediates antiproliferative effects through apoptosis and autophagy in A549 cells
por: Wei, Yanjie, et al.
Publicado: (2018)

Development of small-molecule therapeutics and strategies for targeting RAF kinase in BRAF-mutant colorectal cancer
por: Pan, Jing-hua, et al.
Publicado: (2018)

Targeting Raf Kinase Inhibitory Protein Regulation and Function
por: Yesilkanal, Ali Ekrem, et al.
Publicado: (2018)

Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization
por: Lavoie, Hugo, et al.
Publicado: (2013)

Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
por: Mayrhofer, Johanna E., et al.
Publicado: (2020)

The RAF Kinase Inhibitor Protein (RKIP): Good as Tumour Suppressor, Bad for the Heart
por: Abd Alla, Joshua, et al.
Publicado: (2022)

PLX8394, a RAF inhibitor, inhibits enterovirus 71 replication by blocking RAF/MEK/ERK signaling
por: Wu, Chengyuan, et al.
Publicado: (2023)

Hydroxycamptothecin-loaded nanoparticles enhance target drug delivery and anticancer effect
por: Wang, Anxun, et al.
Publicado: (2008)

Resistance to RAF inhibitors revisited
por: Hartsough, Edward, et al.
Publicado: (2013)

Hydroxycamptothecin regulates scar formation of the filtration channel under scleral flap by inhibiting the proliferation of scleral fibroblasts
por: Gu, Hongwei, et al.
Publicado: (2023)

Discovery of highly potent and selective 7-ethyl-10-hydroxycamptothecin-glucose conjugates as potential anti-colorectal cancer agents
por: Yang, Chao, et al.
Publicado: (2022)

Arabidopsis Raf-Like Mitogen-Activated Protein Kinase Kinase Kinase Gene Raf43 Is Required for Tolerance to Multiple Abiotic Stresses
por: Virk, Nasar, et al.
Publicado: (2015)

Co-Prodrugs of 7-Ethyl-10-hydroxycamptothecin and Vorinostat with in Vitro Hydrolysis and Anticancer Effects
por: Liu, Shuangxi, et al.
Publicado: (2019)

Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells
por: Liu, Zhen, et al.
Publicado: (2022)

Hydroxycamptothecin induces apoptosis and inhibits tumor growth in colon cancer by the downregulation of survivin and XIAP expression
por: Fei, Bojian, et al.
Publicado: (2013)

Negative regulation of mitochondrial VDAC channels by C-Raf kinase
por: Le Mellay, Véronique, et al.
Publicado: (2002)

Raf kinase inhibitor protein combined with phosphorylated extracellular signal-regulated kinase offers valuable prognosis in gastrointestinal stromal tumor
por: Qu, Wen-Zhi, et al.
Publicado: (2023)

Mitochondrial-Targeted Triphenylphosphonium–Hydroxycamptothecin Conjugate and Its Nano-Formulations for Breast Cancer Therapy: In Vitro and In Vivo Investigation
por: Zhang, Kunfeng, et al.
Publicado: (2023)

Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate
por: Zhou, Ting, et al.
Publicado: (2019)

Hydroxycamptothecin Inhibits Peritendinous Adhesion via the Endoplasmic Reticulum Stress-Dependent Apoptosis
por: Yao, Zhixiao, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_b8f25i9tt0s0b8g4v4j7fj0b9h