Cargando…

Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp

Cancer chemotherapy resistance (MDR) is the innate and/or acquired ability of cancer cells to evade the effects of chemotherapeutics and is one of the most pressing major dilemmas in cancer therapy. Chemotherapy resistance can arise due to several host or tumor-related factors. However, most current...

Descripción completa

Detalles Bibliográficos
Autores principales:	Alfarouk, Khalid O, Stock, Christian-Martin, Taylor, Sophie, Walsh, Megan, Muddathir, Abdel Khalig, Verduzco, Daniel, Bashir, Adil H H, Mohammed, Osama Y, Elhassan, Gamal O, Harguindey, Salvador, Reshkin, Stephan J, Ibrahim, Muntaser E, Rauch, Cyril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502609/ https://www.ncbi.nlm.nih.gov/pubmed/26180516 http://dx.doi.org/10.1186/s12935-015-0221-1

Ejemplares similares

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
por: Alfarouk, Khalid O., et al.
Publicado: (2014)

Glycolysis, tumor metabolism, cancer growth and dissemination. A new pH-based etiopathogenic perspective and therapeutic approach to an old cancer question
por: Alfarouk, Khalid O., et al.
Publicado: (2014)

Evolution of Tumor Metabolism might Reflect Carcinogenesis as a Reverse Evolution process (Dismantling of Multicellularity)
por: Alfarouk, Khalid O., et al.
Publicado: (2011)

The Possible Role of Helicobacter pylori in Gastric Cancer and Its Management
por: Alfarouk, Khalid O., et al.
Publicado: (2019)

Of mitochondrion and COVID-19
por: Alfarouk, Khalid Omer, et al.
Publicado: (2021)

The Prime and Integral Cause of Cancer in the Post-Warburg Era
por: Harguindey, Salvador, et al.
Publicado: (2023)

Tumor Acidity as Evolutionary Spite
por: Alfarouk, Khalid O., et al.
Publicado: (2011)

Hydrogen Ion Dynamics as the Fundamental Link between Neurodegenerative Diseases and Cancer: Its Application to the Therapeutics of Neurodegenerative Diseases with Special Emphasis on Multiple Sclerosis
por: Harguindey, Salvador, et al.
Publicado: (2022)

The Pentose Phosphate Pathway Dynamics in Cancer and Its Dependency on Intracellular pH
por: Alfarouk, Khalid O., et al.
Publicado: (2020)

The Interplay of Dysregulated pH and Electrolyte Imbalance in Cancer
por: Alfarouk, Khalid O., et al.
Publicado: (2020)

Hydrogen Ion Dynamics of Cancer and a New Molecular, Biochemical and Metabolic Approach to the Etiopathogenesis and Treatment of Brain Malignancies
por: Harguindey, Salvador, et al.
Publicado: (2019)

Towards an Integral Therapeutic Protocol for Breast Cancer Based upon the New H(+)-Centered Anticancer Paradigm of the Late Post-Warburg Era
por: Harguindey, Salvador, et al.
Publicado: (2020)

Cariporide and other new and powerful NHE1 inhibitors as potentially selective anticancer drugs – an integral molecular/biochemical/metabolic/clinical approach after one hundred years of cancer research
por: Harguindey, Salvador, et al.
Publicado: (2013)

Curing cancer? Further along the new pH-centric road and paradigm
por: Harguindey, S., et al.
Publicado: (2018)

A New and Integral Approach to the Etiopathogenesis and Treatment of Breast Cancer Based upon Its Hydrogen Ion Dynamics
por: Harguindey, Salvador, et al.
Publicado: (2020)

Metabolic Shifts as the Hallmark of Most Common Diseases: The Quest for the Underlying Unity
por: Schwartz, Laurent, et al.
Publicado: (2021)

Vascular measurements correlate with estrogen receptor status
por: Lloyd, Mark C, et al.
Publicado: (2014)

Riparian ecosystems in human cancers
por: Alfarouk, Khalid O, et al.
Publicado: (2013)

Role of pH in Regulating Cancer Pyrimidine Synthesis
por: Alqahtani, Saad Saeed, et al.
Publicado: (2022)

Pathogenesis and Management of COVID-19
por: Alfarouk, Khalid O., et al.
Publicado: (2021)

The possible role of methylglyoxal metabolism in cancer
por: Alfarouk, Khalid O., et al.
Publicado: (2021)

Proton dynamics in cancer
por: Huber, Veronica, et al.
Publicado: (2010)

Hydrogen ion dynamics and the Na(+)/H(+) exchanger in cancer angiogenesis and antiangiogenesis
por: Orive, G, et al.
Publicado: (2003)

Proton pump inhibitors for the treatment of cancer in companion animals
por: Walsh, Megan, et al.
Publicado: (2015)

Tumor Microenvironment Features and Chemoresistance in Pancreatic Ductal Adenocarcinoma: Insights into Targeting Physicochemical Barriers and Metabolism as Therapeutic Approaches
por: Carvalho, Tiago M. A., et al.
Publicado: (2021)

Integrin-Linked Kinase Links Integrin Activation to Invadopodia Function and Invasion via the p(T567)-Ezrin/NHERF1/NHE1 Pathway
por: Greco, Maria Raffaella, et al.
Publicado: (2021)

ADME-Space: a new tool for medicinal chemists to explore ADME properties
por: Bocci, Giovanni, et al.
Publicado: (2017)

Altered expression of ADM and ADM2 by hypoxia regulates migration of trophoblast and HLA-G expression
por: Gu, Changdai, et al.
Publicado: (2020)

Matrine reverses the drug resistance of K562/ADM cells to ADM and VCR via promoting autophagy
por: Li, Zhao, et al.
Publicado: (2020)

Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma: A Physiopathologic and Pharmacologic Review
por: Koltai, Tomas, et al.
Publicado: (2022)

Duality, Entropy and ADM Mass in Supergravity
por: Cerchiai, Bianca L., et al.
Publicado: (2009)

FAF-Drugs: free ADME/tox filtering of compound collections
por: Miteva, Maria A., et al.
Publicado: (2006)

Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
por: Tibbitts, Jay, et al.
Publicado: (2015)

Knockdown of HOXA10 reverses the multidrug resistance of human chronic mylogenous leukemia K562/ADM cells by downregulating P-gp and MRP-1
por: Yi, Ying-Jie, et al.
Publicado: (2023)

Exome sequencing of a colorectal cancer family reveals shared mutation pattern and predisposition circuitry along tumor pathways
por: Suleiman, Suleiman H., et al.
Publicado: (2015)

To ADM or not to ADM? Outcomes of Pre-pectoral Prosthetic Reconstruction after Nipple-Sparing Mastectomy with and without Acellular Dermal Matrix
por: Bushong, E., et al.
Publicado: (2023)

ADM masses for black strings and p-branes
por: Lu, J.X.
Publicado: (1993)

Netupitant PET imaging and ADME studies in humans
por: Spinelli, Tulla, et al.
Publicado: (2014)

An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data
por: James, Alexander D., et al.
Publicado: (2020)

Prediction of In-silico ADME Properties of 1,2-O-Isopropylidene Aldohexose Derivatives
por: Kovačević, Strahinja Z, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_76qotvsgrdem2ogkh3knoim5gi