Cargando…
Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide
The P140 peptide, a 21-mer linear peptide (sequence 131–151) generated from the spliceosomal SNRNP70/U1–70K protein, contains a phosphoserine residue at position 140. It significantly ameliorates clinical manifestations in autoimmune patients with systemic lupus erythematosus and enhances survival i...
Autores principales: | Macri, Christophe, Wang, Fengjuan, Tasset, Inmaculada, Schall, Nicolas, Page, Nicolas, Briand, Jean-Paul, Cuervo, Ana Maria, Muller, Sylviane |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502742/ https://www.ncbi.nlm.nih.gov/pubmed/25719862 http://dx.doi.org/10.1080/15548627.2015.1017179 |
Ejemplares similares
-
In Vivo Remodeling of Altered Autophagy-Lysosomal Pathway by a Phosphopeptide in Lupus
por: Wang, Fengjuan, et al.
Publicado: (2020) -
HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus
por: Page, Nicolas, et al.
Publicado: (2010) -
The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells
por: Page, Nicolas, et al.
Publicado: (2009) -
Macroautophagy is deregulated in murine and human lupus T lymphocytes
por: Gros, Frédéric, et al.
Publicado: (2012) -
Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target
por: Wang, Fengjuan, et al.
Publicado: (2015)