Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles

The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups...

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Autores principales: Dao-Huy, Toan, Haider, Maximilian, Glatz, Fabian, Schnürch, Michael, Mihovilovic, Marko D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2014
Materias:
Full Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502765/
https://www.ncbi.nlm.nih.gov/pubmed/26213483
http://dx.doi.org/10.1002/ejoc.201403125
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author Dao-Huy, Toan
Haider, Maximilian
Glatz, Fabian
Schnürch, Michael
Mihovilovic, Marko D
author_facet Dao-Huy, Toan
Haider, Maximilian
Glatz, Fabian
Schnürch, Michael
Mihovilovic, Marko D
author_sort Dao-Huy, Toan
collection PubMed
description The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan.
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spelling pubmed-45027652015-07-22 Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles Dao-Huy, Toan Haider, Maximilian Glatz, Fabian Schnürch, Michael Mihovilovic, Marko D European J Org Chem Full Papers The direct arylation of benzo[b]furan, benzo[b]thiophene, and indole has been studied by using aromatic bromides as the aryl source. The protocol employing common reagents and a Pd catalyst has led to the regioselective arylation of these heterocycles at the 2-position. A range of functional groups were tolerated, providing quick access to a variety of arylated benzo-fused heterocycles that would be accessible more elaborately using classical synthetic strategies. This is the first systematic study of the direct arylation of benzo[b]furan. WILEY-VCH Verlag 2014-12 2014-11-17 /pmc/articles/PMC4502765/ /pubmed/26213483 http://dx.doi.org/10.1002/ejoc.201403125 Text en © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. https://creativecommons.org/licenses/by/4.0/ © 2014 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Dao-Huy, Toan
Haider, Maximilian
Glatz, Fabian
Schnürch, Michael
Mihovilovic, Marko D
Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title_full Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title_fullStr Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title_full_unstemmed Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title_short Direct Arylation of Benzo[b]furan and Other Benzo-Fused Heterocycles
title_sort direct arylation of benzo[b]furan and other benzo-fused heterocycles
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502765/
https://www.ncbi.nlm.nih.gov/pubmed/26213483
http://dx.doi.org/10.1002/ejoc.201403125
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