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Heat shock response and autophagy—cooperation and control

Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock...

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Detalles Bibliográficos
Autores principales: Dokladny, Karol, Myers, Orrin B, Moseley, Pope L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502786/
https://www.ncbi.nlm.nih.gov/pubmed/25714619
http://dx.doi.org/10.1080/15548627.2015.1009776
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author Dokladny, Karol
Myers, Orrin B
Moseley, Pope L
author_facet Dokladny, Karol
Myers, Orrin B
Moseley, Pope L
author_sort Dokladny, Karol
collection PubMed
description Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems.
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spelling pubmed-45027862016-02-03 Heat shock response and autophagy—cooperation and control Dokladny, Karol Myers, Orrin B Moseley, Pope L Autophagy Review Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems. Taylor & Francis 2015-02-25 /pmc/articles/PMC4502786/ /pubmed/25714619 http://dx.doi.org/10.1080/15548627.2015.1009776 Text en © 2015 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Dokladny, Karol
Myers, Orrin B
Moseley, Pope L
Heat shock response and autophagy—cooperation and control
title Heat shock response and autophagy—cooperation and control
title_full Heat shock response and autophagy—cooperation and control
title_fullStr Heat shock response and autophagy—cooperation and control
title_full_unstemmed Heat shock response and autophagy—cooperation and control
title_short Heat shock response and autophagy—cooperation and control
title_sort heat shock response and autophagy—cooperation and control
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502786/
https://www.ncbi.nlm.nih.gov/pubmed/25714619
http://dx.doi.org/10.1080/15548627.2015.1009776
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