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Heat shock response and autophagy—cooperation and control
Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502786/ https://www.ncbi.nlm.nih.gov/pubmed/25714619 http://dx.doi.org/10.1080/15548627.2015.1009776 |
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author | Dokladny, Karol Myers, Orrin B Moseley, Pope L |
author_facet | Dokladny, Karol Myers, Orrin B Moseley, Pope L |
author_sort | Dokladny, Karol |
collection | PubMed |
description | Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems. |
format | Online Article Text |
id | pubmed-4502786 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-45027862016-02-03 Heat shock response and autophagy—cooperation and control Dokladny, Karol Myers, Orrin B Moseley, Pope L Autophagy Review Protein quality control (proteostasis) depends on constant protein degradation and resynthesis, and is essential for proper homeostasis in systems from single cells to whole organisms. Cells possess several mechanisms and processes to maintain proteostasis. At one end of the spectrum, the heat shock proteins modulate protein folding and repair. At the other end, the proteasome and autophagy as well as other lysosome-dependent systems, function in the degradation of dysfunctional proteins. In this review, we examine how these systems interact to maintain proteostasis. Both the direct cellular data on heat shock control over autophagy and the time course of exercise-associated changes in humans support the model that heat shock response and autophagy are tightly linked. Studying the links between exercise stress and molecular control of proteostasis provides evidence that the heat shock response and autophagy coordinate and undergo sequential activation and downregulation, and that this is essential for proper proteostasis in eukaryotic systems. Taylor & Francis 2015-02-25 /pmc/articles/PMC4502786/ /pubmed/25714619 http://dx.doi.org/10.1080/15548627.2015.1009776 Text en © 2015 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Review Dokladny, Karol Myers, Orrin B Moseley, Pope L Heat shock response and autophagy—cooperation and control |
title | Heat shock response and autophagy—cooperation and control |
title_full | Heat shock response and autophagy—cooperation and control |
title_fullStr | Heat shock response and autophagy—cooperation and control |
title_full_unstemmed | Heat shock response and autophagy—cooperation and control |
title_short | Heat shock response and autophagy—cooperation and control |
title_sort | heat shock response and autophagy—cooperation and control |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502786/ https://www.ncbi.nlm.nih.gov/pubmed/25714619 http://dx.doi.org/10.1080/15548627.2015.1009776 |
work_keys_str_mv | AT dokladnykarol heatshockresponseandautophagycooperationandcontrol AT myersorrinb heatshockresponseandautophagycooperationandcontrol AT moseleypopel heatshockresponseandautophagycooperationandcontrol |