A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**

Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream proc...

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Detalles Bibliográficos
Autores principales: Ingham, Richard J, Battilocchio, Claudio, Fitzpatrick, Daniel E, Sliwinski, Eric, Hawkins, Joel M, Ley, Steven V
Formato: Online Artículo Texto
Lenguaje:English
Publicado: WILEY-VCH Verlag 2015
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502965/
https://www.ncbi.nlm.nih.gov/pubmed/25377747
http://dx.doi.org/10.1002/anie.201409356
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author Ingham, Richard J
Battilocchio, Claudio
Fitzpatrick, Daniel E
Sliwinski, Eric
Hawkins, Joel M
Ley, Steven V
author_facet Ingham, Richard J
Battilocchio, Claudio
Fitzpatrick, Daniel E
Sliwinski, Eric
Hawkins, Joel M
Ley, Steven V
author_sort Ingham, Richard J
collection PubMed
description Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator.
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spelling pubmed-45029652015-07-22 A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences** Ingham, Richard J Battilocchio, Claudio Fitzpatrick, Daniel E Sliwinski, Eric Hawkins, Joel M Ley, Steven V Angew Chem Int Ed Engl Communications Performing reactions in flow can offer major advantages over batch methods. However, laboratory flow chemistry processes are currently often limited to single steps or short sequences due to the complexity involved with operating a multi-step process. Using new modular components for downstream processing, coupled with control technologies, more advanced multi-step flow sequences can be realized. These tools are applied to the synthesis of 2-aminoadamantane-2-carboxylic acid. A system comprising three chemistry steps and three workup steps was developed, having sufficient autonomy and self-regulation to be managed by a single operator. WILEY-VCH Verlag 2015-01-02 2014-11-05 /pmc/articles/PMC4502965/ /pubmed/25377747 http://dx.doi.org/10.1002/anie.201409356 Text en © 2014 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Ingham, Richard J
Battilocchio, Claudio
Fitzpatrick, Daniel E
Sliwinski, Eric
Hawkins, Joel M
Ley, Steven V
A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title_full A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title_fullStr A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title_full_unstemmed A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title_short A Systems Approach towards an Intelligent and Self-Controlling Platform for Integrated Continuous Reaction Sequences**
title_sort systems approach towards an intelligent and self-controlling platform for integrated continuous reaction sequences**
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4502965/
https://www.ncbi.nlm.nih.gov/pubmed/25377747
http://dx.doi.org/10.1002/anie.201409356
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