Predisposition to Childhood Otitis Media and Genetic Polymorphisms within the Toll-Like Receptor 4 (TLR4) Locus

BACKGROUND: Predisposition to childhood otitis media (OM) has a strong genetic component, with polymorphisms in innate immunity genes suspected to contribute to risk. Studies on several genes have been conducted, but most associations have failed to replicate in independent cohorts. METHODS: We inve...

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Detalles Bibliográficos
Autores principales: Hafrén, Lena, Einarsdottir, Elisabet, Kentala, Erna, Hammarén-Malmi, Sari, Bhutta, Mahmood F., MacArthur, Carol J., Wilmot, Beth, Casselbrant, Margaretha, Conley, Yvette P., Weeks, Daniel E., Mandel, Ellen M., Vaarala, Outi, Kallio, Anna, Melin, Merit, Nieminen, Janne K., Leinonen, Eira, Kere, Juha, Mattila, Petri S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503307/
https://www.ncbi.nlm.nih.gov/pubmed/26177520
http://dx.doi.org/10.1371/journal.pone.0132551

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