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Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population

BACKGROUND: The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and...

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Autores principales: Dong, Ying, Chen, Jing, Chen, Zhiqiang, Tian, Chaoyong, Lu, Huaisheng, Ruan, Jigang, Yang, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503434/
https://www.ncbi.nlm.nih.gov/pubmed/26176862
http://dx.doi.org/10.1371/journal.pone.0132797
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author Dong, Ying
Chen, Jing
Chen, Zhiqiang
Tian, Chaoyong
Lu, Huaisheng
Ruan, Jigang
Yang, Wenjun
author_facet Dong, Ying
Chen, Jing
Chen, Zhiqiang
Tian, Chaoyong
Lu, Huaisheng
Ruan, Jigang
Yang, Wenjun
author_sort Dong, Ying
collection PubMed
description BACKGROUND: The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China. METHODS: A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses. RESULTS: One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27–0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05). CONCLUSIONS: These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required.
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spelling pubmed-45034342015-07-17 Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population Dong, Ying Chen, Jing Chen, Zhiqiang Tian, Chaoyong Lu, Huaisheng Ruan, Jigang Yang, Wenjun PLoS One Research Article BACKGROUND: The identification of susceptibility genes for specific types of cancer can provide necessary information for the complete characterization of cancer syndromes. Eight single nucleotide polymorphisms (SNPs), rs465498, rs17728461, rs4488809, rs753955, rs13361707, rs9841504, rs2274223, and rs13042395, were reported by genome wide association studies (GWASs) to be closely related to the susceptibility of lung cancer (LC), gastric cancer (GC) or esophageal cancer (EC) in Han population from northern or southern China. However, Chinese Han people from different geographic areas may have different genetic backgrounds. This study aims to assess the genetic associations of the eight SNPs mentioned above with three cancers risk in a Han population from northwest China. METHODS: A total of 186 cancer-free controls and 436 cases with non-small cell lung cancer (NSCLC) (159 cases), non-cardia GC (167 cases) or EC (110 cases) were enrolled in this study. Chi-square test and polytomous logistic regression analyses were used to estimate the association between eight cancer-related SNPs and three cancers in a Han Chinese population from northwest China. The logistic regression results were adjusted for confounding factors and Benjamini and Hochberg False Discovery Rate (FDR) method was used to adjust the multiple hypothesis tests. Association analyses by cigarette smoking or alcohol drinking status were analyzed by crossover analyses. RESULTS: One of the eight SNPs, rs17728461 was associated with NSCLC susceptibility (in a heterozygous model, OR = 0.44, 95% CI = 0.27–0.72, p = 0.001). Two SNPs, rs753955 and rs13042395, were associated with the risk of non-cardia GC in different genetic models (p < 0.05). No SNPs were associated with EC. The crossover analyses showed that the rs13042395 CT genotype, combined with cigarette smoking or alcohol drinking, could further increase the risk for non-cardia GC (p < 0.05). CONCLUSIONS: These results indicated that rs17728461 may be specifically associated with the risk of NSCLC. rs753955 and rs13042395 were specifically associated with susceptibility to non-cardia GC in Ningxia Han Chinese. Susceptibility-associated polymorphisms in the northwestern Han Chinese were not very consistent with those in the northern Han Chinese or southern Han Chinese. The validation of these findings with a functional evaluation and a larger population is still required. Public Library of Science 2015-07-15 /pmc/articles/PMC4503434/ /pubmed/26176862 http://dx.doi.org/10.1371/journal.pone.0132797 Text en © 2015 Dong et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Dong, Ying
Chen, Jing
Chen, Zhiqiang
Tian, Chaoyong
Lu, Huaisheng
Ruan, Jigang
Yang, Wenjun
Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title_full Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title_fullStr Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title_full_unstemmed Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title_short Evaluating the Association of Eight Polymorphisms with Cancer Susceptibility in a Han Chinese Population
title_sort evaluating the association of eight polymorphisms with cancer susceptibility in a han chinese population
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503434/
https://www.ncbi.nlm.nih.gov/pubmed/26176862
http://dx.doi.org/10.1371/journal.pone.0132797
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