αPIX Is a Trafficking Regulator that Balances Recycling and Degradation of the Epidermal Growth Factor Receptor

Endosomal sorting is an essential control mechanism for signaling through the epidermal growth factor receptor (EGFR). We report here that the guanine nucleotide exchange factor αPIX, which modulates the activity of Rho-GTPases, is a potent bimodal regulator of EGFR trafficking. αPIX interacts with...

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Detalles Bibliográficos
Autores principales: Kortüm, Fanny, Harms, Frederike Leonie, Hennighausen, Natascha, Rosenberger, Georg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503440/
https://www.ncbi.nlm.nih.gov/pubmed/26177020
http://dx.doi.org/10.1371/journal.pone.0132737

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