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Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice

The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named “jabuticabeira” in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressa...

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Autores principales: Sacchet, Cassia, Mocelin, Ricieri, Sachett, Adrieli, Bevilaqua, Fernanda, Chitolina, Rafael, Kuhn, Fernanda, Boligon, Aline Augusti, Athayde, Margareth Linde, Roman Junior, Walter Antonio, Rosemberg, Denis Broock, Dal Magro, Jacir, Conterato, Greicy Michelle Marafiga, Piato, Angelo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503558/
https://www.ncbi.nlm.nih.gov/pubmed/26229543
http://dx.doi.org/10.1155/2015/601503
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author Sacchet, Cassia
Mocelin, Ricieri
Sachett, Adrieli
Bevilaqua, Fernanda
Chitolina, Rafael
Kuhn, Fernanda
Boligon, Aline Augusti
Athayde, Margareth Linde
Roman Junior, Walter Antonio
Rosemberg, Denis Broock
Dal Magro, Jacir
Conterato, Greicy Michelle Marafiga
Piato, Angelo L.
author_facet Sacchet, Cassia
Mocelin, Ricieri
Sachett, Adrieli
Bevilaqua, Fernanda
Chitolina, Rafael
Kuhn, Fernanda
Boligon, Aline Augusti
Athayde, Margareth Linde
Roman Junior, Walter Antonio
Rosemberg, Denis Broock
Dal Magro, Jacir
Conterato, Greicy Michelle Marafiga
Piato, Angelo L.
author_sort Sacchet, Cassia
collection PubMed
description The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named “jabuticabeira” in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins were identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid peroxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800 mg/kg, i.p.) dose-dependently reduced immobility time in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex vivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora.
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spelling pubmed-45035582015-07-30 Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice Sacchet, Cassia Mocelin, Ricieri Sachett, Adrieli Bevilaqua, Fernanda Chitolina, Rafael Kuhn, Fernanda Boligon, Aline Augusti Athayde, Margareth Linde Roman Junior, Walter Antonio Rosemberg, Denis Broock Dal Magro, Jacir Conterato, Greicy Michelle Marafiga Piato, Angelo L. Evid Based Complement Alternat Med Research Article The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named “jabuticabeira” in Brazil and is used in folk medicine to treat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study evaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins were identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid peroxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800 mg/kg, i.p.) dose-dependently reduced immobility time in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex vivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora. Hindawi Publishing Corporation 2015 2015-07-02 /pmc/articles/PMC4503558/ /pubmed/26229543 http://dx.doi.org/10.1155/2015/601503 Text en Copyright © 2015 Cassia Sacchet et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sacchet, Cassia
Mocelin, Ricieri
Sachett, Adrieli
Bevilaqua, Fernanda
Chitolina, Rafael
Kuhn, Fernanda
Boligon, Aline Augusti
Athayde, Margareth Linde
Roman Junior, Walter Antonio
Rosemberg, Denis Broock
Dal Magro, Jacir
Conterato, Greicy Michelle Marafiga
Piato, Angelo L.
Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title_full Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title_fullStr Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title_full_unstemmed Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title_short Antidepressant-Like and Antioxidant Effects of Plinia trunciflora in Mice
title_sort antidepressant-like and antioxidant effects of plinia trunciflora in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503558/
https://www.ncbi.nlm.nih.gov/pubmed/26229543
http://dx.doi.org/10.1155/2015/601503
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