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EpCAM Aptamer-siRNA Chimera Targets and Regress Epithelial Cancer

Epithelial cell adhesion molecule (EpCAM), a cancer stem cell (CSC) marker is over expressed in epithelial cancers and in retinoblastoma (RB). We fabricated an EpCAM targeting aptamer-siRNA chimera and investigated its anti-tumor property and EpCAM intracellular domain (EpICD) mediated signaling in...

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Detalles Bibliográficos
Autores principales:	Subramanian, Nithya, Kanwar, Jagat R., Kanwar, Rupinder K., Sreemanthula, JagadeeshBabu, Biswas, Jyotirmay, Khetan, Vikas, Krishnakumar, Subramanian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503753/ https://www.ncbi.nlm.nih.gov/pubmed/26176230 http://dx.doi.org/10.1371/journal.pone.0132407

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