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Visual representations are dominated by intrinsic fluctuations correlated between areas

Intrinsic cortical dynamics are thought to underlie trial-to-trial variability of visually evoked responses in animal models. Understanding their function in the context of sensory processing and representation is a major current challenge. Here we report that intrinsic cortical dynamics strongly af...

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Autores principales: Henriksson, Linda, Khaligh-Razavi, Seyed-Mahdi, Kay, Kendrick, Kriegeskorte, Nikolaus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503804/
https://www.ncbi.nlm.nih.gov/pubmed/25896934
http://dx.doi.org/10.1016/j.neuroimage.2015.04.026
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author Henriksson, Linda
Khaligh-Razavi, Seyed-Mahdi
Kay, Kendrick
Kriegeskorte, Nikolaus
author_facet Henriksson, Linda
Khaligh-Razavi, Seyed-Mahdi
Kay, Kendrick
Kriegeskorte, Nikolaus
author_sort Henriksson, Linda
collection PubMed
description Intrinsic cortical dynamics are thought to underlie trial-to-trial variability of visually evoked responses in animal models. Understanding their function in the context of sensory processing and representation is a major current challenge. Here we report that intrinsic cortical dynamics strongly affect the representational geometry of a brain region, as reflected in response-pattern dissimilarities, and exaggerate the similarity of representations between brain regions. We characterized the representations in several human visual areas by representational dissimilarity matrices (RDMs) constructed from fMRI response-patterns for natural image stimuli. The RDMs of different visual areas were highly similar when the response-patterns were estimated on the basis of the same trials (sharing intrinsic cortical dynamics), and quite distinct when patterns were estimated on the basis of separate trials (sharing only the stimulus-driven component). We show that the greater similarity of the representational geometries can be explained by coherent fluctuations of regional-mean activation within visual cortex, reflecting intrinsic dynamics. Using separate trials to study stimulus-driven representations revealed clearer distinctions between the representational geometries: a Gabor wavelet pyramid model explained representational geometry in visual areas V1–3 and a categorical animate–inanimate model in the object-responsive lateral occipital cortex.
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spelling pubmed-45038042015-07-21 Visual representations are dominated by intrinsic fluctuations correlated between areas Henriksson, Linda Khaligh-Razavi, Seyed-Mahdi Kay, Kendrick Kriegeskorte, Nikolaus Neuroimage Article Intrinsic cortical dynamics are thought to underlie trial-to-trial variability of visually evoked responses in animal models. Understanding their function in the context of sensory processing and representation is a major current challenge. Here we report that intrinsic cortical dynamics strongly affect the representational geometry of a brain region, as reflected in response-pattern dissimilarities, and exaggerate the similarity of representations between brain regions. We characterized the representations in several human visual areas by representational dissimilarity matrices (RDMs) constructed from fMRI response-patterns for natural image stimuli. The RDMs of different visual areas were highly similar when the response-patterns were estimated on the basis of the same trials (sharing intrinsic cortical dynamics), and quite distinct when patterns were estimated on the basis of separate trials (sharing only the stimulus-driven component). We show that the greater similarity of the representational geometries can be explained by coherent fluctuations of regional-mean activation within visual cortex, reflecting intrinsic dynamics. Using separate trials to study stimulus-driven representations revealed clearer distinctions between the representational geometries: a Gabor wavelet pyramid model explained representational geometry in visual areas V1–3 and a categorical animate–inanimate model in the object-responsive lateral occipital cortex. Academic Press 2015-07-01 /pmc/articles/PMC4503804/ /pubmed/25896934 http://dx.doi.org/10.1016/j.neuroimage.2015.04.026 Text en © 2015 The Authors. Published by Elsevier Inc. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Henriksson, Linda
Khaligh-Razavi, Seyed-Mahdi
Kay, Kendrick
Kriegeskorte, Nikolaus
Visual representations are dominated by intrinsic fluctuations correlated between areas
title Visual representations are dominated by intrinsic fluctuations correlated between areas
title_full Visual representations are dominated by intrinsic fluctuations correlated between areas
title_fullStr Visual representations are dominated by intrinsic fluctuations correlated between areas
title_full_unstemmed Visual representations are dominated by intrinsic fluctuations correlated between areas
title_short Visual representations are dominated by intrinsic fluctuations correlated between areas
title_sort visual representations are dominated by intrinsic fluctuations correlated between areas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503804/
https://www.ncbi.nlm.nih.gov/pubmed/25896934
http://dx.doi.org/10.1016/j.neuroimage.2015.04.026
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