Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity

Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...

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Detalles Bibliográficos
Autores principales: Nedialkova, Danny D., Leidel, Sebastian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503807/
https://www.ncbi.nlm.nih.gov/pubmed/26052047
http://dx.doi.org/10.1016/j.cell.2015.05.022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503807/
https://www.ncbi.nlm.nih.gov/pubmed/26052047
http://dx.doi.org/10.1016/j.cell.2015.05.022

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