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Optimization of Codon Translation Rates via tRNA Modifications Maintains Proteome Integrity
Proteins begin to fold as they emerge from translating ribosomes. The kinetics of ribosome transit along a given mRNA can influence nascent chain folding, but the extent to which individual codon translation rates impact proteome integrity remains unknown. Here, we show that slower decoding of discr...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cell Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503807/ https://www.ncbi.nlm.nih.gov/pubmed/26052047 http://dx.doi.org/10.1016/j.cell.2015.05.022 |