Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells

The mevalonate pathway provides metabolites for post-translational modifications such as farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently occurring regulatory processes can induce an aberrant stimulation of DNA methyltransferase (DNMT1) as well as changes...

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Detalles Bibliográficos
Autores principales: Karlic, Heidrun, Thaler, Roman, Gerner, Christopher, Grunt, Thomas, Proestling, Katharina, Haider, Florian, Varga, Franz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Contributions to Progress and Promise of Epigenetics for Diagnosis and Therapy in Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503872/
https://www.ncbi.nlm.nih.gov/pubmed/25978957
http://dx.doi.org/10.1016/j.cancergen.2015.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503872/
https://www.ncbi.nlm.nih.gov/pubmed/25978957
http://dx.doi.org/10.1016/j.cancergen.2015.03.008

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