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Inhibition of the mevalonate pathway affects epigenetic regulation in cancer cells
The mevalonate pathway provides metabolites for post-translational modifications such as farnesylation, which are critical for the activity of RAS downstream signaling. Subsequently occurring regulatory processes can induce an aberrant stimulation of DNA methyltransferase (DNMT1) as well as changes...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503872/ https://www.ncbi.nlm.nih.gov/pubmed/25978957 http://dx.doi.org/10.1016/j.cancergen.2015.03.008 |