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Rapid proteasomal elimination of 3-hydroxy-3-methylglutaryl-CoA reductase by interferon- [Formula: see text] in primary macrophages requires endogenous 25-hydroxycholesterol synthesis

Interferons (IFNs) play a central role in immunity and emerging evidence suggests that IFN-signalling coordinately regulates sterol biosynthesis in macrophages, via Sterol Regulatory Element-Binding Protein (SREBP) dependent and independent pathways. However, the precise mechanisms and kinetic steps...

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Detalles Bibliográficos
Autores principales:	Lu, Hongjin, Talbot, Simon, Robertson, Kevin A., Watterson, Steven, Forster, Thorsten, Roy, Douglas, Ghazal, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503878/ https://www.ncbi.nlm.nih.gov/pubmed/25759117 http://dx.doi.org/10.1016/j.steroids.2015.02.022

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