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The prevalence of thyroid cancer in patients with hyperthyroidism

OBJECTIVES: To determine the prevalence of thyroid cancer in patients with hyperthyroidism. METHODS: This is a retrospective observational study using the data of 71 Omani patients with a diagnosis of hyperthyroidism due to Grave’s disease, toxic multinodular goiter, and solitary toxic adenoma. Thes...

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Autores principales: Kunjumohamed, Fathimabeebi P., Al-Busaidi, Noor B., Al-Musalhi, Hilal N., Al-Shereiqi, Sulaiman Z., Al-Salmi, Issa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Saudi Medical Journal 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503911/
https://www.ncbi.nlm.nih.gov/pubmed/26108596
http://dx.doi.org/10.15537/smj.2015.7.11463
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author Kunjumohamed, Fathimabeebi P.
Al-Busaidi, Noor B.
Al-Musalhi, Hilal N.
Al-Shereiqi, Sulaiman Z.
Al-Salmi, Issa S.
author_facet Kunjumohamed, Fathimabeebi P.
Al-Busaidi, Noor B.
Al-Musalhi, Hilal N.
Al-Shereiqi, Sulaiman Z.
Al-Salmi, Issa S.
author_sort Kunjumohamed, Fathimabeebi P.
collection PubMed
description OBJECTIVES: To determine the prevalence of thyroid cancer in patients with hyperthyroidism. METHODS: This is a retrospective observational study using the data of 71 Omani patients with a diagnosis of hyperthyroidism due to Grave’s disease, toxic multinodular goiter, and solitary toxic adenoma. These patients underwent thyroidectomy at the Royal Hospital (RH), Muscat, Oman, and were followed up at the National Diabetes and Endocrine Center (NDEC) between 2007 and 2013. The details were collected from the medical records of both the RH and the NDEC. Patients who underwent thyroidectomy for other reasons like non-toxic goiter and hypothyroidism with cancer were excluded from the study. RESULTS: Thyroid cancer was identified in 32.8% (n=23) of patients with hyperthyroidism. Half of these patients 52.1% (n=12) had papillary micro-cancer (intra-thyroidal), and 3 patients with Grave’s disease (13%) had lymph nodes metastasis (loco-regional infiltration. The cancer preponderance was higher in young (n=21, 91.3%) and female patients (n=18, 73.9%). Most patients with thyroid cancer had abnormal ultrasound neck findings and thyroid scintigraphy (99 mTc uptake). CONCLUSION: Many patients with hyperthyroidism in Muscat, Oman, especially those with Grave’s disease, show malignancy, and hence a proper initial evaluation of these patients is required as part of long-term management.
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spelling pubmed-45039112015-07-16 The prevalence of thyroid cancer in patients with hyperthyroidism Kunjumohamed, Fathimabeebi P. Al-Busaidi, Noor B. Al-Musalhi, Hilal N. Al-Shereiqi, Sulaiman Z. Al-Salmi, Issa S. Saudi Med J Brief Communication OBJECTIVES: To determine the prevalence of thyroid cancer in patients with hyperthyroidism. METHODS: This is a retrospective observational study using the data of 71 Omani patients with a diagnosis of hyperthyroidism due to Grave’s disease, toxic multinodular goiter, and solitary toxic adenoma. These patients underwent thyroidectomy at the Royal Hospital (RH), Muscat, Oman, and were followed up at the National Diabetes and Endocrine Center (NDEC) between 2007 and 2013. The details were collected from the medical records of both the RH and the NDEC. Patients who underwent thyroidectomy for other reasons like non-toxic goiter and hypothyroidism with cancer were excluded from the study. RESULTS: Thyroid cancer was identified in 32.8% (n=23) of patients with hyperthyroidism. Half of these patients 52.1% (n=12) had papillary micro-cancer (intra-thyroidal), and 3 patients with Grave’s disease (13%) had lymph nodes metastasis (loco-regional infiltration. The cancer preponderance was higher in young (n=21, 91.3%) and female patients (n=18, 73.9%). Most patients with thyroid cancer had abnormal ultrasound neck findings and thyroid scintigraphy (99 mTc uptake). CONCLUSION: Many patients with hyperthyroidism in Muscat, Oman, especially those with Grave’s disease, show malignancy, and hence a proper initial evaluation of these patients is required as part of long-term management. Saudi Medical Journal 2015-07 /pmc/articles/PMC4503911/ /pubmed/26108596 http://dx.doi.org/10.15537/smj.2015.7.11463 Text en Copyright: © Saudi Medical Journal https://creativecommons.org/licenses/by-nc-sa/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Kunjumohamed, Fathimabeebi P.
Al-Busaidi, Noor B.
Al-Musalhi, Hilal N.
Al-Shereiqi, Sulaiman Z.
Al-Salmi, Issa S.
The prevalence of thyroid cancer in patients with hyperthyroidism
title The prevalence of thyroid cancer in patients with hyperthyroidism
title_full The prevalence of thyroid cancer in patients with hyperthyroidism
title_fullStr The prevalence of thyroid cancer in patients with hyperthyroidism
title_full_unstemmed The prevalence of thyroid cancer in patients with hyperthyroidism
title_short The prevalence of thyroid cancer in patients with hyperthyroidism
title_sort prevalence of thyroid cancer in patients with hyperthyroidism
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503911/
https://www.ncbi.nlm.nih.gov/pubmed/26108596
http://dx.doi.org/10.15537/smj.2015.7.11463
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