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Translocation of Non-Canonical Polypeptides into Cells Using Protective Antigen

A variety of pathogenic bacteria infect host eukaryotic cells using protein toxins, which enter the cytosol and exert their cytotoxic effects. Anthrax lethal toxin, for example, utilizes the membrane-spanning translocase, protective antigen (PA) pore, to deliver the protein toxin lethal factor (LF)...

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Detalles Bibliográficos
Autores principales: Rabideau, Amy E., Liao, Xiaoli, Akçay, Gizem, Pentelute, Bradley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503955/
https://www.ncbi.nlm.nih.gov/pubmed/26178180
http://dx.doi.org/10.1038/srep11944