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Biochemical investigations of the mechanism of action of small molecules ZL006 and IC87201 as potential inhibitors of the nNOS-PDZ/PSD-95-PDZ interactions

ZL006 and IC87201 have been presented as efficient inhibitors of the nNOS/PSD-95 protein-protein interaction and shown great promise in cellular experiments and animal models of ischemic stroke and pain. Here, we investigate the proposed mechanism of action of ZL006 and IC87201 using biochemical and...

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Detalles Bibliográficos
Autores principales:	Bach, Anders, Pedersen, Søren W., Dorr, Liam A., Vallon, Gary, Ripoche, Isabelle, Ducki, Sylvie, Lian, Lu-Yun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503980/ https://www.ncbi.nlm.nih.gov/pubmed/26177569 http://dx.doi.org/10.1038/srep12157

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