Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)(2)) controlled CH activation furnishes regioselectiv...

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Detalles Bibliográficos
Autores principales: Abdelkafi, Hajer, Cintrat, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503988/
https://www.ncbi.nlm.nih.gov/pubmed/26179245
http://dx.doi.org/10.1038/srep12131
Descripción
Sumario:This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)(2)) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.

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