Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation

This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)(2)) controlled CH activation furnishes regioselectiv...

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Autores principales: Abdelkafi, Hajer, Cintrat, Jean-Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503988/
https://www.ncbi.nlm.nih.gov/pubmed/26179245
http://dx.doi.org/10.1038/srep12131
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author Abdelkafi, Hajer
Cintrat, Jean-Christophe
author_facet Abdelkafi, Hajer
Cintrat, Jean-Christophe
author_sort Abdelkafi, Hajer
collection PubMed
description This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)(2)) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain.
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spelling pubmed-45039882015-07-23 Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation Abdelkafi, Hajer Cintrat, Jean-Christophe Sci Rep Article This article reports an efficient CH activation process for regioselective halogenation of 1,4-benzodiazepinones. Direct halogenation with NXS (X = Br, I) affords halogenated benzodiazepinones on the central aromatic ring whereas catalyst (Pd(OAc)(2)) controlled CH activation furnishes regioselectively ortho halogenated benzodiazepinones on the phenyl side chain. Nature Publishing Group 2015-07-16 /pmc/articles/PMC4503988/ /pubmed/26179245 http://dx.doi.org/10.1038/srep12131 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Abdelkafi, Hajer
Cintrat, Jean-Christophe
Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title_full Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title_fullStr Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title_full_unstemmed Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title_short Regioselective Halogenation of 1,4-Benzodiazepinones via CH Activation
title_sort regioselective halogenation of 1,4-benzodiazepinones via ch activation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503988/
https://www.ncbi.nlm.nih.gov/pubmed/26179245
http://dx.doi.org/10.1038/srep12131
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