Regulation of microtubule dynamics by DIAPH3 influences amoeboid tumor cell mechanics and sensitivity to taxanes

Taxanes are widely employed chemotherapies for patients with metastatic prostate and breast cancer. Here, we show that loss of Diaphanous-related formin-3 (DIAPH3), frequently associated with metastatic breast and prostate cancers, correlates with increased sensitivity to taxanes. DIAPH3 interacted...

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Detalles Bibliográficos
Autores principales: Morley, Samantha, You, Sungyong, Pollan, Sara, Choi, Jiyoung, Zhou, Bo, Hager, Martin H., Steadman, Kenneth, Spinelli, Cristiana, Rajendran, Kavitha, Gertych, Arkadiusz, Kim, Jayoung, Adam, Rosalyn M., Yang, Wei, Krishnan, Ramaswamy, Knudsen, Beatrice S., Di Vizio, Dolores, Freeman, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4503992/
https://www.ncbi.nlm.nih.gov/pubmed/26179371
http://dx.doi.org/10.1038/srep12136

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