Accumulation of the PX domain mutant Frank-ter Haar syndrome protein Tks4 in aggresomes

BACKGROUND: Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular localization. RESULTS: Here we demonstrate that the accumulation of Tks4(R43W)...

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Detalles Bibliográficos
Autores principales: Ádám, Csaba, Fekete, Anna, Bőgel, Gábor, Németh, Zsuzsanna, Tőkési, Natália, Ovádi, Judit, Liliom, Károly, Pesti, Szabolcs, Geiszt, Miklós, Buday, László
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504077/
https://www.ncbi.nlm.nih.gov/pubmed/26183326
http://dx.doi.org/10.1186/s12964-015-0108-8

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