Epigenome data release: a participant-centered approach to privacy protection

Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate inte...

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Detalles Bibliográficos
Autores principales: Dyke, Stephanie O. M., Cheung, Warren A., Joly, Yann, Ammerpohl, Ole, Lutsik, Pavlo, Rothstein, Mark A., Caron, Maxime, Busche, Stephan, Bourque, Guillaume, Rönnblom, Lars, Flicek, Paul, Beck, Stephan, Hirst, Martin, Stunnenberg, Henk, Siebert, Reiner, Walter, Jörn, Pastinen, Tomi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504083/
https://www.ncbi.nlm.nih.gov/pubmed/26185018
http://dx.doi.org/10.1186/s13059-015-0723-0
Descripción
Sumario:Large-scale epigenome mapping by the NIH Roadmap Epigenomics Project, the ENCODE Consortium and the International Human Epigenome Consortium (IHEC) produces genome-wide DNA methylation data at one base-pair resolution. We examine how such data can be made open-access while balancing appropriate interpretation and genomic privacy. We propose guidelines for data release that both reduce ambiguity in the interpretation of open-access data and limit immediate access to genetic variation data that are made available through controlled access. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s13059-015-0723-0) contains supplementary material, which is available to authorized users.

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