Orai/CRACM1 and K(Ca)3.1 ion channels interact in the human lung mast cell plasma membrane

BACKGROUND: Orai/CRACM1 ion channels provide the major Ca(2+) influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca(2+)-activated K(+) channel K(Ca)3.1 modulates Ca(2+) influx and the secretory response through hyperpolarisation of the plasma membrane. We hypothesis...

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Detalles Bibliográficos
Autores principales: Duffy, S. Mark, Ashmole, Ian, Smallwood, Dawn T., Leyland, Mark L., Bradding, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504158/
https://www.ncbi.nlm.nih.gov/pubmed/26177720
http://dx.doi.org/10.1186/s12964-015-0112-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504158/
https://www.ncbi.nlm.nih.gov/pubmed/26177720
http://dx.doi.org/10.1186/s12964-015-0112-z

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