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Orai/CRACM1 and K(Ca)3.1 ion channels interact in the human lung mast cell plasma membrane

BACKGROUND: Orai/CRACM1 ion channels provide the major Ca(2+) influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca(2+)-activated K(+) channel K(Ca)3.1 modulates Ca(2+) influx and the secretory response through hyperpolarisation of the plasma membrane. We hypothesis...

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Detalles Bibliográficos
Autores principales:	Duffy, S. Mark, Ashmole, Ian, Smallwood, Dawn T., Leyland, Mark L., Bradding, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504158/ https://www.ncbi.nlm.nih.gov/pubmed/26177720 http://dx.doi.org/10.1186/s12964-015-0112-z

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