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Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review
Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504160/ https://www.ncbi.nlm.nih.gov/pubmed/26178620 http://dx.doi.org/10.1186/s13000-015-0330-0 |
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author | Alhumidi, Ahmed |
author_facet | Alhumidi, Ahmed |
author_sort | Alhumidi, Ahmed |
collection | PubMed |
description | Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T–cell lymphoma (IVNKL) have been reported. Our case is A 47-year-old female presented with erythematous patches and plaques on the lower extremities mimicking panniculitis clinically. A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test. Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases. |
format | Online Article Text |
id | pubmed-4504160 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-45041602015-07-17 Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review Alhumidi, Ahmed Diagn Pathol Case Report Intravascular large cell lymphoma is a rare subtype of extranodal large cell lymphoma characterized by the presence of neoplastic cells within the lumina of small vessels. Most cases of intravascular large cell lymphoma have a B-cell phenotype. To date, 12 cases of intravascular natural killer (NK/)/T–cell lymphoma (IVNKL) have been reported. Our case is A 47-year-old female presented with erythematous patches and plaques on the lower extremities mimicking panniculitis clinically. A skin biopsy revealed intravascular lymphoma (IVL) with a NK/T cell phenotype (positive for CD3, and granzyme B and negative for CD20, CD4, CD8, CD5). The lymphoma cells were also positive for Epstein-Barr virus by Epstein-Barr virus-encoded RNA in situ hybridization test. Because this type of lymphoma is extremely rare, our case is documented and compared with the previously reported cases. BioMed Central 2015-07-16 /pmc/articles/PMC4504160/ /pubmed/26178620 http://dx.doi.org/10.1186/s13000-015-0330-0 Text en © Alhumidi. 2015 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Case Report Alhumidi, Ahmed Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title | Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title_full | Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title_fullStr | Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title_full_unstemmed | Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title_short | Cutaneous Intravascular NK/T-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
title_sort | cutaneous intravascular nk/t-cell lymphoma mimic panniculitis clinically, case report and literature brief review |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504160/ https://www.ncbi.nlm.nih.gov/pubmed/26178620 http://dx.doi.org/10.1186/s13000-015-0330-0 |
work_keys_str_mv | AT alhumidiahmed cutaneousintravascularnktcelllymphomamimicpanniculitisclinicallycasereportandliteraturebriefreview |