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Drugging the unfolded protein response in acute leukemias

The unfolded protein response (UPR), an endoplasmic reticulum (ER) stress-induced signaling cascade, is mediated by three major stress sensors IRE-1α, PERK, and ATF6α. Studies described the UPR as a critical network in selection, adaptation, and survival of cancer cells. While previous reviews focus...

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Detalles Bibliográficos
Autores principales:	Kharabi Masouleh, Behzad, Chevet, Eric, Panse, Jens, Jost, Edgar, O’Dwyer, Michael, Bruemmendorf, Tim H., Samali, Afshin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504168/ https://www.ncbi.nlm.nih.gov/pubmed/26179601 http://dx.doi.org/10.1186/s13045-015-0184-7

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