Telomerase inhibition improves tumor response to radiotherapy in a murine orthotopic model of human glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most frequent and aggressive type of adult brain tumor. Most GBMs express telomerase; a high level of intra-tumoral telomerase activity (TA) is predictive of poor prognosis. Thus, telomerase inhibitors are promising options to treat GBM. These inhibitors increas...

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Detalles Bibliográficos
Autores principales: Ferrandon, Sylvain, Malleval, Céline, El Hamdani, Badia, Battiston-Montagne, Priscillia, Bolbos, Radu, Langlois, Jean-Baptiste, Manas, Patrick, Gryaznov, Sergei M, Alphonse, Gersende, Honnorat, Jérôme, Rodriguez-Lafrasse, Claire, Poncet, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504179/
https://www.ncbi.nlm.nih.gov/pubmed/26183089
http://dx.doi.org/10.1186/s12943-015-0376-3

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