Poly(ADP-ribose) polymerase as a novel regulator of 17β-estradiol-induced cell growth through a control of the estrogen receptor/IGF-1 receptor/PDZK1 axis

BACKGROUND: We and others have extensively investigated the role of PARP-1 in cell growth and demise in response to pathophysiological cues. Most of the clinical trials on PARP inhibitors are targeting primarily estrogen receptor (ER) negative cancers with BRCA-deficiency. It is surprising that the...

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Detalles Bibliográficos
Autores principales: Kim, Hogyoung, Tarhuni, Abdelmetalab, Abd Elmageed, Zakaria Y, Boulares, A Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504350/
https://www.ncbi.nlm.nih.gov/pubmed/26183824
http://dx.doi.org/10.1186/s12967-015-0589-7

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