Excessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model

BACKGROUND: In clinic settings, rel apsed leukemic patients are found to be more fragile to chemotherapy due to delayed or incomplete hematopoietic recovery, and hematopoiesis of these patients seem to be impaired. METHODS: We established a leukemia therapy model with a non-irradiated T cell acute l...

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Detalles Bibliográficos
Autores principales: Jiang, Chuanhe, Hu, Xiaoxia, Wang, Libing, Cheng, Hui, Lin, Yan, Pang, Yakun, Yuan, Weiping, Cheng, Tao, Wang, Jianmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504405/
https://www.ncbi.nlm.nih.gov/pubmed/26183432
http://dx.doi.org/10.1186/s12967-015-0543-8

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