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Mycolactone-Dependent Depletion of Endothelial Cell Thrombomodulin Is Strongly Associated with Fibrin Deposition in Buruli Ulcer Lesions

A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone. Since the underlying mechanism is not known, we have investigated the effect of mycolactone on endothelial cells, focussing on the...

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Detalles Bibliográficos
Autores principales:	Ogbechi, Joy, Ruf, Marie-Thérèse, Hall, Belinda S., Bodman-Smith, Katherine, Vogel, Moritz, Wu, Hua-Lin, Stainer, Alexander, Esmon, Charles T., Ahnström, Josefin, Pluschke, Gerd, Simmonds, Rachel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504485/ https://www.ncbi.nlm.nih.gov/pubmed/26181660 http://dx.doi.org/10.1371/journal.ppat.1005011

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