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Abraxane, the Nanoparticle Formulation of Paclitaxel Can Induce Drug Resistance by Up-Regulation of P-gp
P-glycoprotein (P-gp) can actively pump paclitaxel (PTX) out of cells and induces drug resistance. Abraxane, a nanoparticle (NP) formulation of PTX, has multiple clinical advantages over the single molecule form. However, it is still unclear whether Abraxane overcomes the common small molecule drug...
Autores principales: | Zhao, Minzhi, Lei, Chunni, Yang, Yadong, Bu, Xiangli, Ma, Huailei, Gong, He, Liu, Juan, Fang, Xiangdong, Hu, Zhiyuan, Fang, Qiaojun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504487/ https://www.ncbi.nlm.nih.gov/pubmed/26182353 http://dx.doi.org/10.1371/journal.pone.0131429 |
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