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Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011

OBJECTIVE: To determine the nationwide incidence of non-traumatic subconjunctival hemorrhage (NTSCH) in Taiwan from 2000-2011 and to analyze the risk factors for NTSCH using a case-control analysis. METHODS: This is a population-based cohort administrative database study. Randomly selected 1,000,000...

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Autores principales: Hu, Dan-Ning, Mou, Chih-Hsin, Chao, Shih-Chun, Lin, Ching-Yang, Nien, Chan-Wei, Kuan, Pei-Tzu, Jonas, Jost B., Sung, Fung-Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504497/
https://www.ncbi.nlm.nih.gov/pubmed/26181776
http://dx.doi.org/10.1371/journal.pone.0132762
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author Hu, Dan-Ning
Mou, Chih-Hsin
Chao, Shih-Chun
Lin, Ching-Yang
Nien, Chan-Wei
Kuan, Pei-Tzu
Jonas, Jost B.
Sung, Fung-Chang
author_facet Hu, Dan-Ning
Mou, Chih-Hsin
Chao, Shih-Chun
Lin, Ching-Yang
Nien, Chan-Wei
Kuan, Pei-Tzu
Jonas, Jost B.
Sung, Fung-Chang
author_sort Hu, Dan-Ning
collection PubMed
description OBJECTIVE: To determine the nationwide incidence of non-traumatic subconjunctival hemorrhage (NTSCH) in Taiwan from 2000-2011 and to analyze the risk factors for NTSCH using a case-control analysis. METHODS: This is a population-based cohort administrative database study. Randomly selected 1,000,000 residents from the Taiwan National Health Insurance Research Database in 2000 and followed for 12 years to determine the population incidence of NTSCH. Individuals with the first diagnosis of subconjunctival hemorrhage were identified by the corresponding International Classification of Diseases code (ICD) 372.72. Traumatic subconjunctival hemorrhages (ICD-9 codes 921, 871, 850-854 and 959.01) were excluded. The association of NTSCH with various demographic factors, comorbidities and use of medications was studied by a population based case-control analysis using data of 2008-2011. RESULTS: A total of 67,720 patients with a first-time diagnosis of NTSCH were identified during the 12 years period. The mean annual incidence was 65 per 10,000 individuals (crude incidence) and 60 per 10,000 individuals (age- and sex-standardized incidence). The incidence rate of NTSCH was higher in women than in men, [men-women ratio: 0.80 (95% confidence interval: 0.78-0.81)]. The age-specific incidence decreased from childhood to the group of teenagers, after which it increased to a maximal value of 136.2 per 10,000 people in the age group of 60-69 years. Case-control analysis showed that comorbidities of hypertension, purpura and thrombocytopenia, and the use of aspirin were significantly associated with the risk of NTSCH. CONCLUSIONS: This study indicates that NTSCH is a common eye disease that occurs once in 167 individuals in a general East Asian population per year. It occurs more often in women than in men and the age-specific incidence peaked in the age group of 60-69 years. Hypertension, purpura and thrombocytopenia, and the use of aspirin are the major risk factors for NTSCH.
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spelling pubmed-45044972015-07-17 Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011 Hu, Dan-Ning Mou, Chih-Hsin Chao, Shih-Chun Lin, Ching-Yang Nien, Chan-Wei Kuan, Pei-Tzu Jonas, Jost B. Sung, Fung-Chang PLoS One Research Article OBJECTIVE: To determine the nationwide incidence of non-traumatic subconjunctival hemorrhage (NTSCH) in Taiwan from 2000-2011 and to analyze the risk factors for NTSCH using a case-control analysis. METHODS: This is a population-based cohort administrative database study. Randomly selected 1,000,000 residents from the Taiwan National Health Insurance Research Database in 2000 and followed for 12 years to determine the population incidence of NTSCH. Individuals with the first diagnosis of subconjunctival hemorrhage were identified by the corresponding International Classification of Diseases code (ICD) 372.72. Traumatic subconjunctival hemorrhages (ICD-9 codes 921, 871, 850-854 and 959.01) were excluded. The association of NTSCH with various demographic factors, comorbidities and use of medications was studied by a population based case-control analysis using data of 2008-2011. RESULTS: A total of 67,720 patients with a first-time diagnosis of NTSCH were identified during the 12 years period. The mean annual incidence was 65 per 10,000 individuals (crude incidence) and 60 per 10,000 individuals (age- and sex-standardized incidence). The incidence rate of NTSCH was higher in women than in men, [men-women ratio: 0.80 (95% confidence interval: 0.78-0.81)]. The age-specific incidence decreased from childhood to the group of teenagers, after which it increased to a maximal value of 136.2 per 10,000 people in the age group of 60-69 years. Case-control analysis showed that comorbidities of hypertension, purpura and thrombocytopenia, and the use of aspirin were significantly associated with the risk of NTSCH. CONCLUSIONS: This study indicates that NTSCH is a common eye disease that occurs once in 167 individuals in a general East Asian population per year. It occurs more often in women than in men and the age-specific incidence peaked in the age group of 60-69 years. Hypertension, purpura and thrombocytopenia, and the use of aspirin are the major risk factors for NTSCH. Public Library of Science 2015-07-16 /pmc/articles/PMC4504497/ /pubmed/26181776 http://dx.doi.org/10.1371/journal.pone.0132762 Text en © 2015 Hu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hu, Dan-Ning
Mou, Chih-Hsin
Chao, Shih-Chun
Lin, Ching-Yang
Nien, Chan-Wei
Kuan, Pei-Tzu
Jonas, Jost B.
Sung, Fung-Chang
Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title_full Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title_fullStr Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title_full_unstemmed Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title_short Incidence of Non-Traumatic Subconjunctival Hemorrhage in a Nationwide Study in Taiwan from 2000 to 2011
title_sort incidence of non-traumatic subconjunctival hemorrhage in a nationwide study in taiwan from 2000 to 2011
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504497/
https://www.ncbi.nlm.nih.gov/pubmed/26181776
http://dx.doi.org/10.1371/journal.pone.0132762
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