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The Effect of 5-Aminolevulinic Acid on Cytochrome P450-Mediated Prodrug Activation

Of late, numerous prodrugs are widely used for therapy. The hemeprotein cytochrome P450 (CYP) catalyzes the activation of prodrugs to form active metabolites. Therefore, the activation of CYP function might allow the use of lower doses of prodrugs and decrease toxicity. We hypothesized that the addi...

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Detalles Bibliográficos
Autores principales:	Miura, Mai, Ito, Kensuke, Hayashi, Maiko, Nakajima, Motowo, Tanaka, Tohru, Ogura, Shun-ichiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504516/ https://www.ncbi.nlm.nih.gov/pubmed/26181717 http://dx.doi.org/10.1371/journal.pone.0131793

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