Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA

Genome stability is jeopardized by imbalances of the dNTP pool; such imbalances affect the rate of fork progression. For example, cytidine deaminase (CDA) deficiency leads to an excess of dCTP, slowing the replication fork. We describe here a novel mechanism by which pyrimidine pool disequilibrium c...

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Detalles Bibliográficos
Autores principales: Gemble, Simon, Ahuja, Akshay, Buhagiar-Labarchède, Géraldine, Onclercq-Delic, Rosine, Dairou, Julien, Biard, Denis S. F., Lambert, Sarah, Lopes, Massimo, Amor-Guéret, Mounira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504519/
https://www.ncbi.nlm.nih.gov/pubmed/26181065
http://dx.doi.org/10.1371/journal.pgen.1005384

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