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High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma
Estrogen receptor alpha 36 (ERα36), a truncated variant of ERα, is located in cytoplasm and membrane that is different from other nuclear receptors of ERα family. ERα36 is involved in progression and treatment resistance of a variety of carcinomas. However, the clinical and prognostic significance o...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504609/ https://www.ncbi.nlm.nih.gov/pubmed/26131816 http://dx.doi.org/10.1097/MD.0000000000001048 |
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author | Wang, Qiang Zhang, Wei Yang, Jing Liu, Yu-Lin Yan, Ze-Xuan Guo, Zheng-Jun Li, Yu-Jun Bian, Xiu-Wu |
author_facet | Wang, Qiang Zhang, Wei Yang, Jing Liu, Yu-Lin Yan, Ze-Xuan Guo, Zheng-Jun Li, Yu-Jun Bian, Xiu-Wu |
author_sort | Wang, Qiang |
collection | PubMed |
description | Estrogen receptor alpha 36 (ERα36), a truncated variant of ERα, is located in cytoplasm and membrane that is different from other nuclear receptors of ERα family. ERα36 is involved in progression and treatment resistance of a variety of carcinomas. However, the clinical and prognostic significance of ERα36 in renal tumors have not been fully elucidated. Here, renal tumor tissues from 125 patients were collected and immunohistochemical stained with ERα36 antibody. ERα36 expression level and location in these cases were analyzed for their correlations with clinical characteristics. The differential diagnosis value was also assessed for benign and malignant renal tumors, as well as its prognostic value. The results showed that membrane ERα36 expression was rarely detected in benign tumors but predominantly observed in malignant renal tumors. Kaplan–Meier analysis indicated that significant correlations of high ERα36 level and ERα36 membrane expression were correlated with both poor disease-free survival and overall survival. Univariate and multivariate analysis confirmed that both ERα36 high expression and membrane location can serve as unfavorable prognostic indicators for renal cell carcinoma. It is thus concluded that membrane ERα36 expression is valuable for differential diagnosis of malignant renal tumors from benign ones. Both ERα36 high expression and membrane location indicate poor prognosis in renal cell carcinoma. |
format | Online Article Text |
id | pubmed-4504609 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-45046092015-08-05 High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma Wang, Qiang Zhang, Wei Yang, Jing Liu, Yu-Lin Yan, Ze-Xuan Guo, Zheng-Jun Li, Yu-Jun Bian, Xiu-Wu Medicine (Baltimore) 5700 Estrogen receptor alpha 36 (ERα36), a truncated variant of ERα, is located in cytoplasm and membrane that is different from other nuclear receptors of ERα family. ERα36 is involved in progression and treatment resistance of a variety of carcinomas. However, the clinical and prognostic significance of ERα36 in renal tumors have not been fully elucidated. Here, renal tumor tissues from 125 patients were collected and immunohistochemical stained with ERα36 antibody. ERα36 expression level and location in these cases were analyzed for their correlations with clinical characteristics. The differential diagnosis value was also assessed for benign and malignant renal tumors, as well as its prognostic value. The results showed that membrane ERα36 expression was rarely detected in benign tumors but predominantly observed in malignant renal tumors. Kaplan–Meier analysis indicated that significant correlations of high ERα36 level and ERα36 membrane expression were correlated with both poor disease-free survival and overall survival. Univariate and multivariate analysis confirmed that both ERα36 high expression and membrane location can serve as unfavorable prognostic indicators for renal cell carcinoma. It is thus concluded that membrane ERα36 expression is valuable for differential diagnosis of malignant renal tumors from benign ones. Both ERα36 high expression and membrane location indicate poor prognosis in renal cell carcinoma. Wolters Kluwer Health 2015-07-02 /pmc/articles/PMC4504609/ /pubmed/26131816 http://dx.doi.org/10.1097/MD.0000000000001048 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5700 Wang, Qiang Zhang, Wei Yang, Jing Liu, Yu-Lin Yan, Ze-Xuan Guo, Zheng-Jun Li, Yu-Jun Bian, Xiu-Wu High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title | High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title_full | High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title_fullStr | High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title_full_unstemmed | High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title_short | High ERα36 Expression Level and Membrane Location Predict Poor Prognosis in Renal Cell Carcinoma |
title_sort | high erα36 expression level and membrane location predict poor prognosis in renal cell carcinoma |
topic | 5700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504609/ https://www.ncbi.nlm.nih.gov/pubmed/26131816 http://dx.doi.org/10.1097/MD.0000000000001048 |
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