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Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer
Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with cancer worldwide. However, the clinical effect of TCM on patients with pancreatic cancer remains unclear. This study was aimed to explore the efficacy of TCM on...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504629/ https://www.ncbi.nlm.nih.gov/pubmed/26131801 http://dx.doi.org/10.1097/MD.0000000000001008 |
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author | Yang, Xue Hao, Jian Zhu, Cui-Hong Niu, Yang-Yang Ding, Xiu-Li Liu, Chang Wu, Xiong-Zhi |
author_facet | Yang, Xue Hao, Jian Zhu, Cui-Hong Niu, Yang-Yang Ding, Xiu-Li Liu, Chang Wu, Xiong-Zhi |
author_sort | Yang, Xue |
collection | PubMed |
description | Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with cancer worldwide. However, the clinical effect of TCM on patients with pancreatic cancer remains unclear. This study was aimed to explore the efficacy of TCM on selected patients with pancreatic cancer and to study the usefulness of multimodality treatment, including TCM and western medicine (WM), in pancreatic cancer. From January 2009 to October 2013, 107 patients with pancreatic cancer were included in this study. Kaplan–Meier curves were used to assess the differences in survival time. Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors. Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001). The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261–0.671). The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001). Patients who received multimodality treatment using TCM and WM had the best prognosis with a median OS of 19 months (P < 0.001). Patients with heat-clearing, diuresis-promoting and detoxification TCM treatment had a longer survival time (32.4 months) than those with blood-activating and stasis-dissolving (9.8 months) and tonifying qi and yang treatment (6.1 months; P = 0.008). These results indicate that TCM has an important potential value for improving the prognosis of patients with pancreatic cancer, and multimodality treatment, including TCM and WM, leads to the best prognosis. More importantly, we suggest that heat-clearing, diuresis-promoting, and detoxification TCM treatment may improve the efficacy of TCM in pancreatic cancer. |
format | Online Article Text |
id | pubmed-4504629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-45046292015-08-05 Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer Yang, Xue Hao, Jian Zhu, Cui-Hong Niu, Yang-Yang Ding, Xiu-Li Liu, Chang Wu, Xiong-Zhi Medicine (Baltimore) 3800 Traditional Chinese medicine (TCM) is one of the most common complementary and alternative medicines used in the treatment of patients with cancer worldwide. However, the clinical effect of TCM on patients with pancreatic cancer remains unclear. This study was aimed to explore the efficacy of TCM on selected patients with pancreatic cancer and to study the usefulness of multimodality treatment, including TCM and western medicine (WM), in pancreatic cancer. From January 2009 to October 2013, 107 patients with pancreatic cancer were included in this study. Kaplan–Meier curves were used to assess the differences in survival time. Cox regression analysis was performed to determine survival trends adjusted for clinical and demographic factors. Cox regression analysis suggested that elevated CA19-9 levels (P = 0.048), number of cycles of chemotherapy (P = 0.014), and TCM were independent prognostic factors (P < 0.001). The survival hazards ratio of TCM was 0.419 (95% confidence interval [CI], 0.261–0.671). The median overall survival (OS) was 19 months for patients with TCM treatment, while the median OS was 8 months for those without TCM treatment (P < 0.001). Patients who received multimodality treatment using TCM and WM had the best prognosis with a median OS of 19 months (P < 0.001). Patients with heat-clearing, diuresis-promoting and detoxification TCM treatment had a longer survival time (32.4 months) than those with blood-activating and stasis-dissolving (9.8 months) and tonifying qi and yang treatment (6.1 months; P = 0.008). These results indicate that TCM has an important potential value for improving the prognosis of patients with pancreatic cancer, and multimodality treatment, including TCM and WM, leads to the best prognosis. More importantly, we suggest that heat-clearing, diuresis-promoting, and detoxification TCM treatment may improve the efficacy of TCM in pancreatic cancer. Wolters Kluwer Health 2015-07-02 /pmc/articles/PMC4504629/ /pubmed/26131801 http://dx.doi.org/10.1097/MD.0000000000001008 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 3800 Yang, Xue Hao, Jian Zhu, Cui-Hong Niu, Yang-Yang Ding, Xiu-Li Liu, Chang Wu, Xiong-Zhi Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title | Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title_full | Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title_fullStr | Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title_full_unstemmed | Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title_short | Survival Benefits of Western and Traditional Chinese Medicine Treatment for Patients With Pancreatic Cancer |
title_sort | survival benefits of western and traditional chinese medicine treatment for patients with pancreatic cancer |
topic | 3800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504629/ https://www.ncbi.nlm.nih.gov/pubmed/26131801 http://dx.doi.org/10.1097/MD.0000000000001008 |
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