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Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review
Insulinoma is a rare endocrine tumor that can cause a wide variety of symptoms, including abnormal nocturnal behavior. We report on 3 patients with insulinoma who presented with abnormal nocturnal behavior and injury during sleep, which simulated rapid eye movement (REM) sleep behavior disorder (RBD...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504631/ https://www.ncbi.nlm.nih.gov/pubmed/26107678 http://dx.doi.org/10.1097/MD.0000000000001065 |
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author | Suzuki, Keisuke Kawasaki, Akiko Miyamoto, Masayuki Miyamoto, Tomoyuki Kanbayashi, Takashi Sato, Masatoshi Shimizu, Tetsuo Hirata, Koichi |
author_facet | Suzuki, Keisuke Kawasaki, Akiko Miyamoto, Masayuki Miyamoto, Tomoyuki Kanbayashi, Takashi Sato, Masatoshi Shimizu, Tetsuo Hirata, Koichi |
author_sort | Suzuki, Keisuke |
collection | PubMed |
description | Insulinoma is a rare endocrine tumor that can cause a wide variety of symptoms, including abnormal nocturnal behavior. We report on 3 patients with insulinoma who presented with abnormal nocturnal behavior and injury during sleep, which simulated rapid eye movement (REM) sleep behavior disorder (RBD). In case 1, the fasting glucose level was 15 mg/dL, and insulin levels were elevated (15 μU/mL). In case 3, when the patient was transferred to the hospital because of a disturbance of consciousness, hypoglycemia (29 mg/dL) was detected. In contrast, in case 2, fasting glucose sampling did not indicate hypoglycemia, but continuous glucose monitoring revealed nocturnal hypoglycemia. The time from initial symptoms to a diagnosis of insulinoma ranged from 7 months to 2 years. All 3 patients had previously received anticonvulsant drugs for suspected epilepsy, but the medications were ineffective. Polysomnography showed no evidence of REM sleep without atonia in any of the 3 patients. No patient remembered any events that occurred during sleep. When a patient manifests abnormal behavior during the night and early morning, glucose monitoring should be performed, especially during the night and early morning. Clinicians should be aware that although insulinomas are rare, they can mimic parasomnias, such as RBD. |
format | Online Article Text |
id | pubmed-4504631 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-45046312015-08-05 Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review Suzuki, Keisuke Kawasaki, Akiko Miyamoto, Masayuki Miyamoto, Tomoyuki Kanbayashi, Takashi Sato, Masatoshi Shimizu, Tetsuo Hirata, Koichi Medicine (Baltimore) 5300 Insulinoma is a rare endocrine tumor that can cause a wide variety of symptoms, including abnormal nocturnal behavior. We report on 3 patients with insulinoma who presented with abnormal nocturnal behavior and injury during sleep, which simulated rapid eye movement (REM) sleep behavior disorder (RBD). In case 1, the fasting glucose level was 15 mg/dL, and insulin levels were elevated (15 μU/mL). In case 3, when the patient was transferred to the hospital because of a disturbance of consciousness, hypoglycemia (29 mg/dL) was detected. In contrast, in case 2, fasting glucose sampling did not indicate hypoglycemia, but continuous glucose monitoring revealed nocturnal hypoglycemia. The time from initial symptoms to a diagnosis of insulinoma ranged from 7 months to 2 years. All 3 patients had previously received anticonvulsant drugs for suspected epilepsy, but the medications were ineffective. Polysomnography showed no evidence of REM sleep without atonia in any of the 3 patients. No patient remembered any events that occurred during sleep. When a patient manifests abnormal behavior during the night and early morning, glucose monitoring should be performed, especially during the night and early morning. Clinicians should be aware that although insulinomas are rare, they can mimic parasomnias, such as RBD. Wolters Kluwer Health 2015-06-26 /pmc/articles/PMC4504631/ /pubmed/26107678 http://dx.doi.org/10.1097/MD.0000000000001065 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5300 Suzuki, Keisuke Kawasaki, Akiko Miyamoto, Masayuki Miyamoto, Tomoyuki Kanbayashi, Takashi Sato, Masatoshi Shimizu, Tetsuo Hirata, Koichi Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title | Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title_full | Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title_fullStr | Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title_full_unstemmed | Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title_short | Insulinoma Masquerading as Rapid Eye Movement Sleep Behavior Disorder: Case Series and Literature Review |
title_sort | insulinoma masquerading as rapid eye movement sleep behavior disorder: case series and literature review |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504631/ https://www.ncbi.nlm.nih.gov/pubmed/26107678 http://dx.doi.org/10.1097/MD.0000000000001065 |
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