Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase A (TrkAIg2) Domain Construct for Binding Site Elucidation in Drug Discovery

[Image: see text] The tyrosine kinase A (TrkA) receptor is a validated therapeutic intervention point for a wide range of conditions. TrkA activation by nerve growth factor (NGF) binding the second extracellular immunoglobulin (TrkAIg2) domain triggers intracellular signaling cascades. In the periph...

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Detalles Bibliográficos
Autores principales: Shoemark, Debbie K., Williams, Christopher, Fahey, Mark S., Watson, Judy J., Tyler, Sue J., Scoltock, Simon J., Ellis, Rosamund Z., Wickenden, Elaine, Burton, Antony J., Hemmings, Jennifer L., Bailey, Christopher D., Dawbarn, David, Jane, David E., Willis, Christine L., Sessions, Richard B., Allen, Shelley J., Crump, Matthew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504729/
https://www.ncbi.nlm.nih.gov/pubmed/25454499
http://dx.doi.org/10.1021/jm501307e

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