First-in-Human Evaluation of the Safety and Immunogenicity of a Recombinant Vesicular Stomatitis Virus Human Immunodeficiency Virus-1 gag Vaccine (HVTN 090)

Background. We report the first-in-human safety and immunogenicity evaluation of a highly attenuated, replication-competent recombinant vesicular stomatitis virus (rVSV) human immunodeficiency virus (HIV)-1 vaccine. Methods. Sixty healthy, HIV-1-uninfected adults were enrolled in a randomized, doubl...

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Detalles Bibliográficos
Autores principales: Fuchs, Jonathan D., Frank, Ian, Elizaga, Marnie L., Allen, Mary, Frahm, Nicole, Kochar, Nidhi, Li, Sue, Edupuganti, Srilatha, Kalams, Spyros A., Tomaras, Georgia D., Sheets, Rebecca, Pensiero, Michael, Tremblay, Marc A., Higgins, Terry J., Latham, Theresa, Egan, Michael A., Clarke, David K., Eldridge, John H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Major Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504730/
https://www.ncbi.nlm.nih.gov/pubmed/26199949
http://dx.doi.org/10.1093/ofid/ofv082

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