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Unusual skin manifestation of hand, foot and mouth disease associated with coxsackievirus A6: cases report

BACKGROUND: Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection. It is a health problem in young children under 5 years of age worldwide. The common causative agents are coxsackievirus A 16 (CA16) and enterovirus 71 (EV71). In recent years, coxsackie...

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Detalles Bibliográficos
Autores principales: Chatproedprai, Susheera, Tempark, Therdpong, Wanlapakorn, Nasamon, Puenpa, Jiratchaya, Wananukul, Siriwan, Poovorawan, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504872/
https://www.ncbi.nlm.nih.gov/pubmed/26203408
http://dx.doi.org/10.1186/s40064-015-1143-z
Descripción
Sumario:BACKGROUND: Hand, food, and mouth disease (HFMD) is a highly contagious disease caused by enteroviruses infection. It is a health problem in young children under 5 years of age worldwide. The common causative agents are coxsackievirus A 16 (CA16) and enterovirus 71 (EV71). In recent years, coxsackievirus A6 (CA6) has emerged to be one of the major etiologic agents of HFMD worldwide including in Thailand. CASE DESCRIPTION: We reported cases with unusual skin manifestations of CA6-associated HFMD such as widespread severe cutaneous eruption, large vesicles (varicelliform), purpuric-like lesions or Gianotti–Crosti like eruptions. DISCUSSION AND EVALUATION: Molecular characterization of the CA6 strains from those patients found that all were clustered in the same group of CA6 that are currently circulating in Thailand. CONCLUSIONS: Clinicians need to be aware of the expanded range of cutaneous findings in CA6-associated HFMD in order to properly consider the diagnosis, management and prevention.