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Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder

OBJECTIVE: To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders. METHODS: The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were cl...

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Autores principales: Kim, Sung-Wan, Dodd, Seetal, Berk, Lesley, Kulkarni, Jayashri, de Castella, Anthony, Fitzgerald, Paul B., Kim, Jae-Min, Yoon, Jin-Sang, Berk, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Neuropsychiatric Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504917/
https://www.ncbi.nlm.nih.gov/pubmed/26207128
http://dx.doi.org/10.4306/pi.2015.12.3.349
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author Kim, Sung-Wan
Dodd, Seetal
Berk, Lesley
Kulkarni, Jayashri
de Castella, Anthony
Fitzgerald, Paul B.
Kim, Jae-Min
Yoon, Jin-Sang
Berk, Michael
author_facet Kim, Sung-Wan
Dodd, Seetal
Berk, Lesley
Kulkarni, Jayashri
de Castella, Anthony
Fitzgerald, Paul B.
Kim, Jae-Min
Yoon, Jin-Sang
Berk, Michael
author_sort Kim, Sung-Wan
collection PubMed
description OBJECTIVE: To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders. METHODS: The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were classified as regular cannabis users (three times or more per week) or non-users. The primary outcome measure was the achievement of remission on the evaluations during the 24 months. RESULTS: Of the 234 participants for whom data was available, 25 (10.7%) were regular cannabis users, and the group comprised significantly more males than females. In the total population, cannabis use was significantly associated with decreased likelihood of remission during the 24-month follow-up period. Subgroup analyses showed that cannabis use was significantly associated with lower remission rates on the Hamilton Depression Rating Scale in females (n=139) and patients prescribed mood stabilizers alone (n=151), whereas in males (n=95) and patients prescribed olanzapine and/or a mood stabilizer (n=83), cannabis use was significantly associated with lower remission rates on the Young Mania Rating Scale. Remission rates were lowest in the concurrent cannabis and tobacco smoking group (n=22) followed by the tobacco smoking only group (n=97), and the non-smoker group (n=116). The post-hoc analysis revealed that all remission rates were significantly lower in the concurrent cannabis and the tobacco smoking group compared to the non-smoker group. CONCLUSION: Cannabis use negatively affects the long-term clinical outcome in patients with bipolar spectrum disorders. A comprehensive assessment and integrated management of cannabis use are required to achieve better treatment outcomes for bipolar spectrum disorders.
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spelling pubmed-45049172015-07-23 Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder Kim, Sung-Wan Dodd, Seetal Berk, Lesley Kulkarni, Jayashri de Castella, Anthony Fitzgerald, Paul B. Kim, Jae-Min Yoon, Jin-Sang Berk, Michael Psychiatry Investig Original Article OBJECTIVE: To investigate the impact of regular cannabis use on long-term remission of mood symptoms in bipolar spectrum disorders. METHODS: The 24-month prospective observational study included patients (n=239) with bipolar I disorder and schizoaffective disorder, bipolar type. Participants were classified as regular cannabis users (three times or more per week) or non-users. The primary outcome measure was the achievement of remission on the evaluations during the 24 months. RESULTS: Of the 234 participants for whom data was available, 25 (10.7%) were regular cannabis users, and the group comprised significantly more males than females. In the total population, cannabis use was significantly associated with decreased likelihood of remission during the 24-month follow-up period. Subgroup analyses showed that cannabis use was significantly associated with lower remission rates on the Hamilton Depression Rating Scale in females (n=139) and patients prescribed mood stabilizers alone (n=151), whereas in males (n=95) and patients prescribed olanzapine and/or a mood stabilizer (n=83), cannabis use was significantly associated with lower remission rates on the Young Mania Rating Scale. Remission rates were lowest in the concurrent cannabis and tobacco smoking group (n=22) followed by the tobacco smoking only group (n=97), and the non-smoker group (n=116). The post-hoc analysis revealed that all remission rates were significantly lower in the concurrent cannabis and the tobacco smoking group compared to the non-smoker group. CONCLUSION: Cannabis use negatively affects the long-term clinical outcome in patients with bipolar spectrum disorders. A comprehensive assessment and integrated management of cannabis use are required to achieve better treatment outcomes for bipolar spectrum disorders. Korean Neuropsychiatric Association 2015-07 2015-07-06 /pmc/articles/PMC4504917/ /pubmed/26207128 http://dx.doi.org/10.4306/pi.2015.12.3.349 Text en Copyright © 2015 Korean Neuropsychiatric Association http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Sung-Wan
Dodd, Seetal
Berk, Lesley
Kulkarni, Jayashri
de Castella, Anthony
Fitzgerald, Paul B.
Kim, Jae-Min
Yoon, Jin-Sang
Berk, Michael
Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title_full Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title_fullStr Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title_full_unstemmed Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title_short Impact of Cannabis Use on Long-Term Remission in Bipolar I and Schizoaffective Disorder
title_sort impact of cannabis use on long-term remission in bipolar i and schizoaffective disorder
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504917/
https://www.ncbi.nlm.nih.gov/pubmed/26207128
http://dx.doi.org/10.4306/pi.2015.12.3.349
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