Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration

We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in G...

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Autores principales: Gibbons, Linda, Rollinson, Sara, Thompson, Jennifer C., Robinson, Andrew, Davidson, Yvonne S., Richardson, Anna, Neary, David, Pickering-Brown, Stuart M., Snowden, Julie S., Mann, David M.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Genetic Report Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504979/
https://www.ncbi.nlm.nih.gov/pubmed/25435337
http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.023
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author Gibbons, Linda
Rollinson, Sara
Thompson, Jennifer C.
Robinson, Andrew
Davidson, Yvonne S.
Richardson, Anna
Neary, David
Pickering-Brown, Stuart M.
Snowden, Julie S.
Mann, David M.A.
author_facet Gibbons, Linda
Rollinson, Sara
Thompson, Jennifer C.
Robinson, Andrew
Davidson, Yvonne S.
Richardson, Anna
Neary, David
Pickering-Brown, Stuart M.
Snowden, Julie S.
Mann, David M.A.
author_sort Gibbons, Linda
collection PubMed
description We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes.
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spelling pubmed-45049792015-07-21 Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration Gibbons, Linda Rollinson, Sara Thompson, Jennifer C. Robinson, Andrew Davidson, Yvonne S. Richardson, Anna Neary, David Pickering-Brown, Stuart M. Snowden, Julie S. Mann, David M.A. Neurobiol Aging Genetic Report Abstract We have measured plasma progranulin and interleukin-6 in 230 patients with frontotemporal lobar degeneration (FTLD), 104 patients with Alzheimer's disease, and 161 control subjects. We have replicated previous findings of decreased levels of progranulin protein in FTLD because of mutations in GRN and show this is not observed in FTLD cases because of other causes. interleukin-6 levels were increased in FTLD overall, but these did not discriminate between clinical and genetic subtypes. Elsevier 2015-03 /pmc/articles/PMC4504979/ /pubmed/25435337 http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.023 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Genetic Report Abstract
Gibbons, Linda
Rollinson, Sara
Thompson, Jennifer C.
Robinson, Andrew
Davidson, Yvonne S.
Richardson, Anna
Neary, David
Pickering-Brown, Stuart M.
Snowden, Julie S.
Mann, David M.A.
Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title_full Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title_fullStr Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title_full_unstemmed Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title_short Plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
title_sort plasma levels of progranulin and interleukin-6 in frontotemporal lobar degeneration
topic Genetic Report Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504979/
https://www.ncbi.nlm.nih.gov/pubmed/25435337
http://dx.doi.org/10.1016/j.neurobiolaging.2014.10.023
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