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Clinical and laboratory characteristics of neonatal hypocalcemia
PURPOSE: To describe the clinical characteristics of full-term neonates with hypocalcemia and to suggest factors associated with neonatal hypocalcemia METHODS: The medical records of full-term neonates with hypocalcemia were reviewed. Hypocalcemia was defined as an ionized calcium (iCa) concentratio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Society of Pediatric Endocrinology
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504995/ https://www.ncbi.nlm.nih.gov/pubmed/26191512 http://dx.doi.org/10.6065/apem.2015.20.2.86 |
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author | Cho, Won Im Yu, Hyeoh Won Chung, Hye Rim Shin, Choong Ho Yang, Sei Won Choi, Chang Won Kim, Beyong Il |
author_facet | Cho, Won Im Yu, Hyeoh Won Chung, Hye Rim Shin, Choong Ho Yang, Sei Won Choi, Chang Won Kim, Beyong Il |
author_sort | Cho, Won Im |
collection | PubMed |
description | PURPOSE: To describe the clinical characteristics of full-term neonates with hypocalcemia and to suggest factors associated with neonatal hypocalcemia METHODS: The medical records of full-term neonates with hypocalcemia were reviewed. Hypocalcemia was defined as an ionized calcium (iCa) concentration of <4 mg/dL. Parathyroid hormone (PTH) insufficiency was defined as a serum PTH level of <60 pg/mL or a serum phosphorus level higher than the serum calcium level in the presence of hypocalcemia. RESULTS: Fifty-three neonates were enrolled. The median age at diagnosis of hypocalcemia was 3 days. In all the neonates, formula feeding predominance was observed. Thirty-eight neonates (69.8%) were compatible with PTH insufficiency. The number of formula-fed neonates was significantly higher than that of breast-fed patients among neonates with PTH insufficiency (P=0.017). Intact PTH was negatively correlated with serum phosphorus levels. Twelve out of 14 neonates (85.7%) had 25-hydroxy vitamin D (25OHD) levels <20 ng/mL and 9 neonates (64.3%) had 25OHD levels <10 ng/mL. Twenty-one neonates had hypocalcemic tetany. The serum calcium and iCa concentrations of neonates with tetany were 4.2-8.3 mg/dL and 1.85-3.88 mg/dL, respectively. Three neonates showed symptomatic hypocalcemia with calcium levels over 7.5 mg/dL. Among the 16 neonates who underwent electroencephalography (EEG), 12 had abnormalities, which normalized after 1-2 months. CONCLUSION: Formula milk feeding, PTH insufficiency and low serum vitamin D concentration are associated with the development of neonatal hypocalcemia. Symptoms such as tetany and QT interval prolongation can develop in relatively mild hypocalcemia. Moreover, transient neonatal hypocalcemia can cause transient EEG abnormalities. |
format | Online Article Text |
id | pubmed-4504995 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | The Korean Society of Pediatric Endocrinology |
record_format | MEDLINE/PubMed |
spelling | pubmed-45049952015-07-17 Clinical and laboratory characteristics of neonatal hypocalcemia Cho, Won Im Yu, Hyeoh Won Chung, Hye Rim Shin, Choong Ho Yang, Sei Won Choi, Chang Won Kim, Beyong Il Ann Pediatr Endocrinol Metab Original Article PURPOSE: To describe the clinical characteristics of full-term neonates with hypocalcemia and to suggest factors associated with neonatal hypocalcemia METHODS: The medical records of full-term neonates with hypocalcemia were reviewed. Hypocalcemia was defined as an ionized calcium (iCa) concentration of <4 mg/dL. Parathyroid hormone (PTH) insufficiency was defined as a serum PTH level of <60 pg/mL or a serum phosphorus level higher than the serum calcium level in the presence of hypocalcemia. RESULTS: Fifty-three neonates were enrolled. The median age at diagnosis of hypocalcemia was 3 days. In all the neonates, formula feeding predominance was observed. Thirty-eight neonates (69.8%) were compatible with PTH insufficiency. The number of formula-fed neonates was significantly higher than that of breast-fed patients among neonates with PTH insufficiency (P=0.017). Intact PTH was negatively correlated with serum phosphorus levels. Twelve out of 14 neonates (85.7%) had 25-hydroxy vitamin D (25OHD) levels <20 ng/mL and 9 neonates (64.3%) had 25OHD levels <10 ng/mL. Twenty-one neonates had hypocalcemic tetany. The serum calcium and iCa concentrations of neonates with tetany were 4.2-8.3 mg/dL and 1.85-3.88 mg/dL, respectively. Three neonates showed symptomatic hypocalcemia with calcium levels over 7.5 mg/dL. Among the 16 neonates who underwent electroencephalography (EEG), 12 had abnormalities, which normalized after 1-2 months. CONCLUSION: Formula milk feeding, PTH insufficiency and low serum vitamin D concentration are associated with the development of neonatal hypocalcemia. Symptoms such as tetany and QT interval prolongation can develop in relatively mild hypocalcemia. Moreover, transient neonatal hypocalcemia can cause transient EEG abnormalities. The Korean Society of Pediatric Endocrinology 2015-06 2015-06-30 /pmc/articles/PMC4504995/ /pubmed/26191512 http://dx.doi.org/10.6065/apem.2015.20.2.86 Text en © 2015 Annals of Pediatric Endocrinology & Metabolism http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Cho, Won Im Yu, Hyeoh Won Chung, Hye Rim Shin, Choong Ho Yang, Sei Won Choi, Chang Won Kim, Beyong Il Clinical and laboratory characteristics of neonatal hypocalcemia |
title | Clinical and laboratory characteristics of neonatal hypocalcemia |
title_full | Clinical and laboratory characteristics of neonatal hypocalcemia |
title_fullStr | Clinical and laboratory characteristics of neonatal hypocalcemia |
title_full_unstemmed | Clinical and laboratory characteristics of neonatal hypocalcemia |
title_short | Clinical and laboratory characteristics of neonatal hypocalcemia |
title_sort | clinical and laboratory characteristics of neonatal hypocalcemia |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504995/ https://www.ncbi.nlm.nih.gov/pubmed/26191512 http://dx.doi.org/10.6065/apem.2015.20.2.86 |
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