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Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases

The prognostic value of the primary lesion pretreatment apparent diffusion coefficient (ADC), which is obtained by diffusion-weighted magnetic resonance imaging (MR-DWI), remains unknown in nasopharyngeal carcinoma (NPC). Thus, to investigate whether the pretreatment ADC value as measured from the p...

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Autores principales: Zhang, Yuan, Liu, Xu, Zhang, Yun, Li, Wen-Fei, Chen, Lei, Mao, Yan-Ping, Shen, Jing-Xian, Zhang, Fan, Peng, Hao, Liu, Qing, Sun, Ying, Ma, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505330/
https://www.ncbi.nlm.nih.gov/pubmed/26184509
http://dx.doi.org/10.1038/srep12242
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author Zhang, Yuan
Liu, Xu
Zhang, Yun
Li, Wen-Fei
Chen, Lei
Mao, Yan-Ping
Shen, Jing-Xian
Zhang, Fan
Peng, Hao
Liu, Qing
Sun, Ying
Ma, Jun
author_facet Zhang, Yuan
Liu, Xu
Zhang, Yun
Li, Wen-Fei
Chen, Lei
Mao, Yan-Ping
Shen, Jing-Xian
Zhang, Fan
Peng, Hao
Liu, Qing
Sun, Ying
Ma, Jun
author_sort Zhang, Yuan
collection PubMed
description The prognostic value of the primary lesion pretreatment apparent diffusion coefficient (ADC), which is obtained by diffusion-weighted magnetic resonance imaging (MR-DWI), remains unknown in nasopharyngeal carcinoma (NPC). Thus, to investigate whether the pretreatment ADC value as measured from the primary site on MR-DWI is an independent prognostic factor in NPC, we retrospectively reviewed a cohort of 541 patients with histologically-proven stage I-IVB NPC. All patients underwent MRI using a 3-Tesla system (Trio Tim; Siemens, Erlangen Germany). To calculate ADC, the primary lesion was designated on the ADC map at the level of the largest tumor diameter to cover most of the lesion, avoiding cystic or necrotic components. Median and mean (±SD) pretreatment ADC were 0.713 and 0.716 ± 0.079 × 10(−3) mm(2)/s, respectively. Univariate and multivariate analysis confirmed high pretreatment ADC was a good prognostic factor for poor local relapse-free survival and disease-free survival. Furthermore, the area under the ROC curve for prediction of local failure significantly increased when pretreatment ADC was combined with T classification (P = 0.004). Thus, pretreatment ADC might provide useful information for predicting outcome and selecting high-risk patients appropriate for more aggressive therapy. Further studies are warranted to investigate the biological basis of this observation.
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spelling pubmed-45053302015-07-23 Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases Zhang, Yuan Liu, Xu Zhang, Yun Li, Wen-Fei Chen, Lei Mao, Yan-Ping Shen, Jing-Xian Zhang, Fan Peng, Hao Liu, Qing Sun, Ying Ma, Jun Sci Rep Article The prognostic value of the primary lesion pretreatment apparent diffusion coefficient (ADC), which is obtained by diffusion-weighted magnetic resonance imaging (MR-DWI), remains unknown in nasopharyngeal carcinoma (NPC). Thus, to investigate whether the pretreatment ADC value as measured from the primary site on MR-DWI is an independent prognostic factor in NPC, we retrospectively reviewed a cohort of 541 patients with histologically-proven stage I-IVB NPC. All patients underwent MRI using a 3-Tesla system (Trio Tim; Siemens, Erlangen Germany). To calculate ADC, the primary lesion was designated on the ADC map at the level of the largest tumor diameter to cover most of the lesion, avoiding cystic or necrotic components. Median and mean (±SD) pretreatment ADC were 0.713 and 0.716 ± 0.079 × 10(−3) mm(2)/s, respectively. Univariate and multivariate analysis confirmed high pretreatment ADC was a good prognostic factor for poor local relapse-free survival and disease-free survival. Furthermore, the area under the ROC curve for prediction of local failure significantly increased when pretreatment ADC was combined with T classification (P = 0.004). Thus, pretreatment ADC might provide useful information for predicting outcome and selecting high-risk patients appropriate for more aggressive therapy. Further studies are warranted to investigate the biological basis of this observation. Nature Publishing Group 2015-07-17 /pmc/articles/PMC4505330/ /pubmed/26184509 http://dx.doi.org/10.1038/srep12242 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Yuan
Liu, Xu
Zhang, Yun
Li, Wen-Fei
Chen, Lei
Mao, Yan-Ping
Shen, Jing-Xian
Zhang, Fan
Peng, Hao
Liu, Qing
Sun, Ying
Ma, Jun
Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title_full Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title_fullStr Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title_full_unstemmed Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title_short Prognostic value of the primary lesion apparent diffusion coefficient (ADC) in nasopharyngeal carcinoma: a retrospective study of 541 cases
title_sort prognostic value of the primary lesion apparent diffusion coefficient (adc) in nasopharyngeal carcinoma: a retrospective study of 541 cases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505330/
https://www.ncbi.nlm.nih.gov/pubmed/26184509
http://dx.doi.org/10.1038/srep12242
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