Targeted therapies in melanoma: Translational research at its finest

The therapeutic landscape for advanced melanoma has expanded in recent years. This expansion has largely been driven by investigational work in melanoma tumor biology and immunology that has been successfully translated to the clinical setting. Molecular evidence generated through benchside experime...

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Detalles Bibliográficos
Autores principales: Ho, Allen W., Tsao, Hensin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505740/
https://www.ncbi.nlm.nih.gov/pubmed/26174532
http://dx.doi.org/10.1038/jid.2015.14
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author Ho, Allen W.
Tsao, Hensin
author_facet Ho, Allen W.
Tsao, Hensin
author_sort Ho, Allen W.
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description The therapeutic landscape for advanced melanoma has expanded in recent years. This expansion has largely been driven by investigational work in melanoma tumor biology and immunology that has been successfully translated to the clinical setting. Molecular evidence generated through benchside experimentation identified BRAF and MEK as key molecular targets in melanoma. This commentary will highlight this work and provide a rationale for the continued importance of translational work in the field of targeted melanoma therapies.
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spelling pubmed-45057402016-01-31 Targeted therapies in melanoma: Translational research at its finest Ho, Allen W. Tsao, Hensin J Invest Dermatol Article The therapeutic landscape for advanced melanoma has expanded in recent years. This expansion has largely been driven by investigational work in melanoma tumor biology and immunology that has been successfully translated to the clinical setting. Molecular evidence generated through benchside experimentation identified BRAF and MEK as key molecular targets in melanoma. This commentary will highlight this work and provide a rationale for the continued importance of translational work in the field of targeted melanoma therapies. 2015-08 /pmc/articles/PMC4505740/ /pubmed/26174532 http://dx.doi.org/10.1038/jid.2015.14 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Ho, Allen W.
Tsao, Hensin
Targeted therapies in melanoma: Translational research at its finest
title Targeted therapies in melanoma: Translational research at its finest
title_full Targeted therapies in melanoma: Translational research at its finest
title_fullStr Targeted therapies in melanoma: Translational research at its finest
title_full_unstemmed Targeted therapies in melanoma: Translational research at its finest
title_short Targeted therapies in melanoma: Translational research at its finest
title_sort targeted therapies in melanoma: translational research at its finest
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4505740/
https://www.ncbi.nlm.nih.gov/pubmed/26174532
http://dx.doi.org/10.1038/jid.2015.14
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